# Growth arrest specific 6

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21110911](https://www.wikidata.org/wiki/Q21110911)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/GAS6)  
**Source**: https://4ort.xyz/entity/growth-arrest-specific-6


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q14393)
3. Q20641742
4. [Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
5. [Gas6-mediated signaling is dependent on the engagement of its gamma-carboxyglutamic acid domain with phosphatidylserine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
6. [TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
7. [Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
8. [The role of gamma-carboxylation in the anti-apoptotic function of gas6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
9. [Reevaluation of the roles of protein S and gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
10. [Endogenous Gas6 and Ca2+ -channel activation modulate phagocytosis by retinal pigment epithelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
12. [Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
13. [The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
14. [Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
16. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14393&geneProductId=UniProtKB:Q14393)
17. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14393&geneProductId=UniProtKB:Q14393)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14393&geneProductId=UniProtKB:Q14393)
19. [GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
20. [The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
21. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
22. [The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
23. [GAS6-induced signaling in human endothelial cells is mediated by FOXO1a](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
24. [Androgen receptor-dependent transactivation of growth arrest-specific gene 6 mediates inhibitory effects of testosterone on vascular calcification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
25. [Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
26. [Role of the growth arrest-specific gene 6 (gas6) product in thrombus stabilization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14393)
27. Ensembl Release 99
28. UMLS 2023
29. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)