# GRB2 associated binding protein 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116882](https://www.wikidata.org/wiki/Q21116882)  
**Source**: https://4ort.xyz/entity/grb2-associated-binding-protein-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13480)
3. Q20641742
4. [Modifier variant of METTL13 suppresses human GAB1-associated profound deafness](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
5. [Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
6. [Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
7. [Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
8. [Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
9. [Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
10. [Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
11. [A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
12. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
13. [A human MAP kinase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
14. [Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
15. [Large-scale structural analysis of the classical human protein tyrosine phosphatome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
16. [Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
17. [Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
18. [Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
19. [Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
20. [Charting the molecular network of the drug target Bcr-Abl](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
21. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
22. [Co-clustering of Fcgamma and B cell receptors induces dephosphorylation of the Grb2-associated binder 1 docking protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
23. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
24. [Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
25. [Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
26. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13480&geneProductId=UniProtKB:Q13480)
27. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
28. [A Grb2-associated docking protein in EGF- and insulin-receptor signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
29. [The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
30. [Vascular importance of the miR-212/132 cluster.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480)
31. Ensembl Release 99