# granulin precursor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21110419](https://www.wikidata.org/wiki/Q21110419)  
**Source**: https://4ort.xyz/entity/granulin-precursor


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
4. [Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
5. [Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
6. [Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
7. [Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
8. [Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
9. [Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
10. [Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
11. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
12. [Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
13. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
14. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
15. [Protein interactions of the transcription factor Hoxa1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
16. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
17. [A novel role for drebrin in regulating progranulin bioactivity in bladder cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
18. [Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
19. [Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
20. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28799&geneProductId=UniProtKB:P28799)
21. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
22. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28799&geneProductId=UniProtKB:P28799)
23. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28799&geneProductId=UniProtKB:P28799)
24. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28799&geneProductId=UniProtKB:P28799)
25. [The lysosomal protein cathepsin L is a progranulin protease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28799&geneProductId=UniProtKB:P28799)
26. [Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28799&geneProductId=UniProtKB:P28799)
27. [Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28799&geneProductId=UniProtKB:P28799)
28. [Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28799&geneProductId=UniProtKB:P28799)
29. [Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
30. [MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
31. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
32. [The lysosomal protein cathepsin L is a progranulin protease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
33. [MicroRNA-588 suppresses tumor cell migration and invasion by targeting GRN in lung squamous cell carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
34. [Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799)
35. Ensembl Release 99
36. UMLS 2023