# glycogen synthase kinase 3 beta

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5514576](https://www.wikidata.org/wiki/Q5514576)  
**Source**: https://4ort.xyz/entity/glycogen-synthase-kinase-3-beta-q5514576


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545157)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1201170)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL362558)
6. [UniProt](http://www.uniprot.org/uniprot/P49841.txt?195)
7. [Swiss-Prot](http://www.uniprot.org/uniprot/P49841.txt?version=197)
8. Q20641742
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
10. [Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
11. [NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
12. [The regulation and deregulation of Wnt signaling by PARK genes in health and disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841)
13. [The importance of Wnt signalling for neurodegeneration in Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841)
14. [A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841)
16. [Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
17. [Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841)
18. [Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841)
19. [Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841)
20. [GSK3B polymorphisms alter transcription and splicing in Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841)
21. [Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841)
22. [Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841)
23. [Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841)
24. [Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841)
25. [Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
26. [Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841)
27. [The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841)
28. [Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
29. [GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
30. [The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
31. [GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
32. [Human Dynamin-like Protein Interacts with the Glycogen Synthase Kinase 3β](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
33. [Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
34. [GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
35. [Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
36. [Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
37. [14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on Ser9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
38. [Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
39. [A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
40. [Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
41. [PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
42. [Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
43. [Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
44. [Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
45. [Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
46. [Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
47. [The protein interaction landscape of the human CMGC kinase group](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
48. [Oncogenic Function of DACT1 in Colon Cancer through the Regulation of β-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
49. [The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)
50. [Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841)