# Glycogen synthase kinase 3 beta

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28556609](https://www.wikidata.org/wiki/Q28556609)  
**Source**: https://4ort.xyz/entity/glycogen-synthase-kinase-3-beta-q28556609


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
4. [Molecular cloning and expression of glycogen synthase kinase-3/factor A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
5. [LTP inhibits LTD in the hippocampus via regulation of GSK3beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
6. [Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
7. [Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
8. [Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
9. [Dp71f modulates GSK3-beta recruitment to the beta1-integrin adhesion complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
10. [Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
11. [Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
12. [Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
13. [An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
14. [The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
15. [Baculovirus-mediated expression and characterisation of rat glycogen synthase kinase-3 beta, the mammalian homologue of the Drosophila melanogaster zeste-white 3sgg homeotic gene product](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
16. [Regulation of dishevelled and beta-catenin in rat skeletal muscle: an alternative exercise-induced GSK-3beta signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
17. [Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
18. [Recruitment of active glycogen synthase kinase-3 into neuronal lipid rafts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
19. [Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase-3beta-mediated suppression of mitochondrial permeability transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
20. [Different localization of tau protein kinase I/glycogen synthase kinase-3 beta from glycogen synthase kinase-3 alpha in cerebellum mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
21. [The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
22. [Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
23. [Phosphorylation of threonine-19 of PSD-95 by GSK-3β is required for PSD-95 mobilization and long-term depression.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
24. [Regulation of p70S6k, GSK-3beta, and calcineurin in rat striated muscle during aging](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
25. [Zinc stimulates glucose consumption by modulating the insulin signaling pathway in L6 myotubes: essential roles of Akt-GLUT4, GSK3β and mTOR-S6K1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
26. [Inhibition of Glycogen Synthase Kinase 3β Activity with Lithium In Vitro Attenuates Sepsis-Induced Changes in Muscle Protein Turnover](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
27. [Chronic psychotropic drug treatment causes differential expression of Reelin signaling system in frontal cortex of rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
28. [Treadmill training regulates β-catenin signaling through phosphorylation of GSK-3β in lumbar vertebrae of ovariectomized rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
29. [GSK-3beta regulation in skeletal muscles by adrenaline and insulin: evidence that PKA and PKB regulate different pools of GSK-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
30. [Roles of TNF-α, GSK-3β and RANKL in the occurrence and development of diabetic osteoporosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
31. [Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
32. [Purinergic P2X7 receptor mediates acetaldehyde-induced hepatic stellate cells activation via PKC-dependent GSK3β pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
33. [Protective effect of erythropoietin against ketamine-induced apoptosis in cultured rat cortical neurons: involvement of PI3K/Akt and GSK-3 beta pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
34. [Glycogen synthase kinase 3beta-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor kappaB signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
35. [ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
36. [An essential role for the integrin-linked kinase-glycogen synthase kinase-3 beta pathway during dendrite initiation and growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
37. [Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase-3 beta and a caspase-9-dependent apoptosis in cerebellar granule neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
38. [GSK-3β Inhibition Suppresses Instability-induced Osteolysis by a Dual Action on Osteoblast and Osteoclast Differentiation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
39. [GSK-3beta activity is increased in skeletal muscle after burn injury in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
40. [Tension force-induced bone formation in orthodontic tooth movement via modulation of the GSK-3β/β-catenin signaling pathway.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
41. [Neuroprotective effects of atypical D1 receptor agonist SKF83959 are mediated via D1 receptor-dependent inhibition of glycogen synthase kinase-3 beta and a receptor-independent anti-oxidative action](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
42. [Prohibitin confers cytoprotection against ISO-induced hypertrophy in H9c2 cells via attenuation of oxidative stress and modulation of Akt/Gsk-3β signaling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
43. [Microtubule stabilization specifies initial neuronal polarization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
44. [Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
45. [Iron-induced oxidative injury differentially regulates PI3K/Akt/GSK3beta pathway in synaptic endings from adult and aged rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
46. [Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
47. [Inhibitory effect of oxymatrine on hepatocyte apoptosis via TLR4/PI3K/Akt/GSK-3β signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
48. [Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18266&geneProductId=UniProtKB:P18266)
49. [miR‐145 inhibits isoproterenol‐induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)
50. [Concomitant degradation of beta-catenin and GSK-3 beta potently contributes to glutamate-induced neurotoxicity in rat hippocampal slice cultures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18266)