# Glycogen synthase kinase 3 alpha

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5514565](https://www.wikidata.org/wiki/Q5514565)  
**Source**: https://4ort.xyz/entity/glycogen-synthase-kinase-3-alpha-q5514565


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1201170)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL362558)
4. [UniProt](http://www.uniprot.org/uniprot/P49840.txt?156)
5. [Swiss-Prot](http://www.uniprot.org/uniprot/P49840.txt?version=158)
6. Q20641742
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840)
9. [Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840)
10. [Glycogen synthase kinase 3: more than a namesake](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840)
11. [GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
12. [The protein interaction landscape of the human CMGC kinase group](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
13. [Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
14. [Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
15. [A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
16. [Phosphorylation of NBR1 by GSK3 modulates protein aggregation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
17. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
18. [The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
19. [Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
20. [The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
21. [Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
22. [Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
23. [Roles of tau protein in health and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
24. [Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
25. [Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
26. [Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
27. [Glycogen synthase kinase 3: more than a namesake](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
28. [Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
29. [Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
30. [A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840)
31. [Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
32. [A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
33. [Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840)
34. [Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
35. [GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840)
36. Ensembl Release 99
37. Identifiers.org