# Glutamate ionotropic receptor NMDA type subunit 2B

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21115816](https://www.wikidata.org/wiki/Q21115816)  
**Source**: https://4ort.xyz/entity/glutamate-ionotropic-receptor-nmda-type-subunit-2b-q21115816


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL467084)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2068839)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1255840)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2107771)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL395091)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL742)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL41306)
10. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1714)
11. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1569)
12. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200395)
13. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13224)
14. Q20641742
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
16. [Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
17. [Analysis of NR3A receptor subunits in human native NMDA receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
18. [A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
19. [Proteome-wide analysis of phospho-regulated PDZ domain interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
20. [Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
21. [Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
22. [Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin-dependent protein kinase II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
23. [Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
24. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224)
25. [Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224)
26. [Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224)
27. [Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
28. [Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
29. [Amyloid-β Receptors: The Good, the Bad, and the Prion Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
30. [Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
31. [Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
32. [Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
33. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
34. [Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224)
35. [Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224)
36. [Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224)
37. [Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224)
38. [Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
39. [Memory enhancement by targeting Cdk5 regulation of NR2B.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
40. [Genetic enhancement of learning and memory in mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224)
41. [Enhanced ethanol inhibition of recombinant N-methyl-D-aspartate receptors by magnesium: role of NR3A subunits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
42. [Genetic enhancement of learning and memory in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224)
43. Ensembl Release 99