# Glutamate ionotropic receptor NMDA type subunit 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21118862](https://www.wikidata.org/wiki/Q21118862)  
**Source**: https://4ort.xyz/entity/glutamate-ionotropic-receptor-nmda-type-subunit-1


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL467084)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2068839)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1255840)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2107771)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL395091)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL742)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL41306)
10. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1714)
11. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1569)
12. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200395)
13. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q05586)
14. Q20641742
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586)
16. [Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586)
17. [GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586)
18. [Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586)
19. [Analysis of NR3A receptor subunits in human native NMDA receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586)
20. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586)
21. [Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586)
22. [Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586)
23. [Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586)
24. [GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586)
25. [Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586)
26. [Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586)
27. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586)
28. [Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586)
29. [Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586)
30. [Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q05586)
31. [NMDA spikes in basal dendrites of cortical pyramidal neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586)
32. [Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586)
33. [Enhanced ethanol inhibition of recombinant N-methyl-D-aspartate receptors by magnesium: role of NR3A subunits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586)
34. [A β‐amyloid oligomer directly modulates P/Q‐type calcium currents inXenopusoocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05586)
35. Ensembl Release 99
36. Transporter Classification database