# Glutamate cysteine ligase, modifier subunit

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28558991](https://www.wikidata.org/wiki/Q28558991)  
**Source**: https://4ort.xyz/entity/glutamate-cysteine-ligase-modifier-subunit


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P48508)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48508)
5. [Knockdown of glutamate-cysteine ligase by small hairpin RNA reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48508)
6. [Amino acid sequence and function of the light subunit of rat kidney gamma-glutamylcysteine synthetase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48508)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48508)
8. [Differential regulation of glutamate-cysteine ligase subunit expression and increased holoenzyme formation in response to cysteine deprivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48508)
9. [Age-related changes in glutathione and glutathione-related enzymes in rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48508)
10. [Rice protein improves oxidative stress by regulating glutathione metabolism and attenuating oxidative damage to lipids and proteins in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48508)
11. [Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48508)
12. [HGF suppresses high glucose-mediated oxidative stress in mesangial cells by activation of PKG and inhibition of PKA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48508)
13. [Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48508)
14. [FSH and bFGF stimulate the production of glutathione in cultured rat Sertoli cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48508)
15. [Gonadotropin regulation of glutamate cysteine ligase catalytic and modifier subunit expression in rat ovary is subunit and follicle stage specific](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48508)
16. [Thyroid hormone promotes glutathione synthesis in astrocytes by up regulation of glutamate cysteine ligase through differential stimulation of its catalytic and modulator subunit mRNAs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48508)
17. ensembl Release 106