# Glutamate-cysteine ligase, catalytic subunit

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28559815](https://www.wikidata.org/wiki/Q28559815)  
**Source**: https://4ort.xyz/entity/glutamate-cysteine-ligase-catalytic-subunit


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P19468)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19468)
5. [Knockdown of Glutamate-Cysteine Ligase by Small Hairpin RNA Reveals That Both Catalytic and Modulatory Subunits Are Essential for the Survival of Primary Neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19468)
6. [Stable transfection of Chinese hamster ovary cells with glutamate-cysteine ligase catalytic subunit cDNA confers increased resistance to tert-butyl hydroperoxide toxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19468)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19468)
8. [Differential regulation of glutamate–cysteine ligase subunit expression and increased holoenzyme formation in response to cysteine deprivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19468)
9. [Aging Impairs the Expression of the Catalytic Subunit of Glutamate Cysteine Ligase in Soleus Muscle Under Stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19468)
10. [Rice protein improves oxidative stress by regulating glutathione metabolism and attenuating oxidative damage to lipids and proteins in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19468)
11. [Insulin Signaling Regulates γ-Glutamylcysteine Ligase Catalytic Subunit Expression in Primary Cultured Rat Hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19468)
12. [HGF suppresses high glucose-mediated oxidative stress in mesangial cells by activation of PKG and inhibition of PKA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19468)
13. [FSH and bFGF stimulate the production of glutathione in cultured rat Sertoli cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19468)
14. [Gonadotropin regulation of glutamate cysteine ligase catalytic and modifier subunit expression in rat ovary is subunit and follicle stage specific](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19468)
15. [Enhanced Expression of Pulmonary γ-Glutamylcysteine Synthetase Heavy Subunit in Rats Exposed to Cadmium Aerosols](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19468)
16. [Adenoviral Overexpression of the Glutamylcysteine Ligase Catalytic Subunit Protects Pancreatic Islets against Oxidative Stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19468)
17. [Cyclic Stretch Magnitude and Duration Affect Rat Alveolar Epithelial Gene Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19468)
18. [Thyroid hormone promotes glutathione synthesis in astrocytes by up regulation of glutamate cysteine ligase through differential stimulation of its catalytic and modulator subunit mRNAs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19468)
19. [Mechanism and Significance of Changes in Glutamate-Cysteine Ligase Expression during Hepatic Fibrogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19468)
20. ensembl Release 106