Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: ROK family
additional property: PropertyValue
  property ID: P361
  value: UDP-N-acetylglucosamine 2-epimerase,UDP-hydrolysing
additional property: PropertyValue
  property ID: P361
  value: UDP-N-acetylglucosamine 2-epimerase domain, protein family
additional property: PropertyValue
  property ID: P527
  value: UDP-N-acetylglucosamine 2-epimerase domain
additional property: PropertyValue
  property ID: P637
  value: NP_001121699
additional property: PropertyValue
  property ID: P637
  value: NP_001177312
additional property: PropertyValue
  property ID: P637
  value: NP_001177313
additional property: PropertyValue
  property ID: P638
  value: 2YHW
additional property: PropertyValue
  property ID: P638
  value: 2YHY
additional property: PropertyValue
  property ID: P638
  value: 2YI1
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P680
  value: hydrolase activity, hydrolyzing O-glycosyl compounds
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: cytosol
additional property: PropertyValue
  property ID: P682
  value: phosphorylation
additional property: PropertyValue
  property ID: P682
  value: cell adhesion
additional property: PropertyValue
  property ID: P682
  value: N-acetylneuraminate metabolic process
additional property: PropertyValue
  property ID: P702
  value: GNE
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000379839
additional property: PropertyValue
  property ID: P705
  value: ENSP00000414760
additional property: PropertyValue
  property ID: P705
  value: ENSP00000437765
additional property: PropertyValue
  property ID: P2888
  value: https://identifiers.org/uniprot:Q9Y223
additional property: PropertyValue
  property ID: P2888
  value: http://purl.uniprot.org/uniprot/Q9Y223
additional property: PropertyValue
  property ID: P2888
  value: https://www.ncbi.nlm.nih.gov/protein/Q9Y223
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 12
      unique citations norm: 0.005
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 12
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q9Y223
    source count: 1
    confidence: 0.2
  P361:
    value: Q24739880
    source count: 1
    confidence: 0.2
    value label: ROK family
  P361:
    value: Q24787810
    source count: 1
    confidence: 0.2
    value label: UDP-N-acetylglucosamine 2-epimerase,UDP-hydrolysing
  P361:
    value: Q83133588
    source count: 1
    confidence: 0.2
    value label: UDP-N-acetylglucosamine 2-epimerase domain, protein family
  P527:
    value: Q24721922
    source count: 1
    confidence: 0.2
    value label: UDP-N-acetylglucosamine 2-epimerase domain
  P637:
    value: NP_001121699
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001177312
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001177313
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001177317
    source count: 1
    confidence: 0.2
  P637:
    value: NP_005467
    source count: 1
    confidence: 0.2
  P638:
    value: 2YHW
    source count: 1
    confidence: 0.2
  P638:
    value: 2YHY
    source count: 1
    confidence: 0.2
  P638:
    value: 2YI1
    source count: 1
    confidence: 0.2
  P638:
    value: 3EO3
    source count: 1
    confidence: 0.2
  P638:
    value: 4ZHT
    source count: 1
    confidence: 0.2
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding
  P680:
    value: Q167149
    source count: 2
    confidence: 0.4
    value label: protein binding
  P680:
    value: Q14874306
    source count: 1
    confidence: 0.2
    value label: hydrolase activity, hydrolyzing O-glycosyl compounds
  P680:
    value: Q14863082
    source count: 1
    confidence: 0.2
    value label: kinase activity
  P680:
    value: Q14817981
    source count: 1
    confidence: 0.2
    value label: ATP binding
  P681:
    value: Q79899
    source count: 2
    confidence: 0.4
    value label: cytoplasm
  P681:
    value: Q220599
    source count: 1
    confidence: 0.2
    value label: cytosol

value: Q242736
source count: 1
confidence: 0.2
value label: phosphorylation

value: Q187640
source count: 1
confidence: 0.2
value label: cell adhesion

value: Q21106659
source count: 1
confidence: 0.2
value label: N-acetylneuraminate metabolic process

value: Q1057
source count: 1
confidence: 0.2
value label: metabolism

value: Q21101571
source count: 1
confidence: 0.2
value label: UDP-N-acetylglucosamine metabolic process

value: Q18034960
source count: 1
confidence: 0.2
value label: GNE

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000379839
source count: 1
confidence: 0.2

value: ENSP00000414760
source count: 1
confidence: 0.2

value: ENSP00000437765
source count: 1
confidence: 0.2

value: ENSP00000439155
source count: 1
confidence: 0.2

value: ENSP00000445117
source count: 1
confidence: 0.2

value: https://identifiers.org/uniprot:Q9Y223
source count: 1
confidence: 0.2

value: http://purl.uniprot.org/uniprot/Q9Y223
source count: 1
confidence: 0.2

value: https://www.ncbi.nlm.nih.gov/protein/Q9Y223
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: A proteome-scale map of the human interactome network
stated in qid: Q24307146
retrieved: 2019-05-09

source: UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) binds to alpha-actinin 1: novel pathways in skeletal muscle?
stated in qid: Q33344453
retrieved: 2019-05-09

source: A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase
stated in qid: Q24313492
retrieved: 2019-04-08

source: Mutations in the human UDP-N-acetylglucosamine 2-epimerase gene define the disease sialuria and the allosteric site of the enzyme
stated in qid: Q24540069
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation
stated in qid: Q22010061
retrieved: 2019-05-09

source: InterPro Release 71.0
stated in qid: Q58943792

source: Identifiers.org
stated in qid: Q16335163

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21106661
domain: protein
level: standard
html url: https://4ort.xyz/entity/glucosamine-udp-n-acetyl-2-epimerase-n-acetylmannosamine-kinase
markdown url: https://4ort.xyz/entity/glucosamine-udp-n-acetyl-2-epimerase-n-acetylmannosamine-kinase.md
facts url summary: https://4ort.xyz/entity/glucosamine-udp-n-acetyl-2-epimerase-n-acetylmannosamine-kinase/facts.json
facts url standard: https://4ort.xyz/entity/glucosamine-udp-n-acetyl-2-epimerase-n-acetylmannosamine-kinase/facts.json
facts url full: https://4ort.xyz/entity/glucosamine-udp-n-acetyl-2-epimerase-n-acetylmannosamine-kinase/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-07T02:42:11.854380Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:47:25.717321+00:00Z