# glucokinase

> mammalian protein found in Homo sapiens known to act as signal transducer for fructose swodkoreceptor GCKR/GKRP

**Wikidata**: [Q425185](https://www.wikidata.org/wiki/Q425185)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Glucokinase)  
**Source**: https://4ort.xyz/entity/glucokinase


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3219124)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35557)
6. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35557)
7. [Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35557)
8. [Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35557)
9. [Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35557)
10. [Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35557)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35557&geneProductId=UniProtKB:P35557)
12. [Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35557&geneProductId=UniProtKB:P35557)
13. [Activating mutations in the human glucokinase gene revealed by genetic selection](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35557&geneProductId=UniProtKB:P35557)
14. [Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35557&geneProductId=UniProtKB:P35557)
15. [Insights into the pathogenicity of rare missense GCK variants from the identification and functional characterization of compound heterozygous and double mutations inherited in cis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35557&geneProductId=UniProtKB:P35557)
16. [Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35557&geneProductId=UniProtKB:P35557)
17. [Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35557&geneProductId=UniProtKB:P35557)
18. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35557&geneProductId=UniProtKB:P35557)
19. [Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35557)
20. [Activating mutations in the human glucokinase gene revealed by genetic selection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35557)
21. [Insights into the pathogenicity of rare missense GCK variants from the identification and functional characterization of compound heterozygous and double mutations inherited in cis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35557)
22. [Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35557)
23. [Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35557)
24. [Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35557)
25. [Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35557&geneProductId=UniProtKB:P35557)
26. [Organization of the human glucokinase regulator gene GCKR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35557)
27. Ensembl Release 99
28. Identifiers.org
29. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)