# Glucokinase

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28558380](https://www.wikidata.org/wiki/Q28558380)  
**Source**: https://4ort.xyz/entity/glucokinase-q28558380


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
4. [Kinetic studies of rat liver hexokinase D ('glucokinase') in non-co-operative conditions show an ordered mechanism with MgADP as the last product to be released](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
5. [Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
6. [Relationships between concentration of hepatic intermediary metabolites and induction of the key glycolytic enzymes in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
7. [Defect in glucokinase translocation in Zucker diabetic fatty rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
8. [Cyclic adenosine 3',5'-monophosphate increases pancreatic glucokinase activity and gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
9. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
10. [Interaction of glucokinase with the liver regulatory protein is conferred by leucine-asparagine motifs of the enzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
11. [Glucokinase and glucokinase regulatory proteins are functionally coexpressed before birth in the rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
12. [Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
13. [A novel cytosolic dual specificity phosphatase, interacting with glucokinase, increases glucose phosphorylation rate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
14. [Contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
15. [An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
16. [Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
17. [Glucokinase regulatory protein is associated with mitochondria in hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
18. [Co-localization of glucokinase with actin filaments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
19. [Glucokinase is located in secretory granules of pancreatic D‐cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
20. [Glucokinase is concentrated in insulin-secretory granules of pancreatic B-cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
21. [Nutrient-dependent distribution of insulin and glucokinase immunoreactivities in rat pancreatic beta cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
22. [Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
23. [Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
24. [Glucokinase is the likely mediator of glucosensing in both glucose-excited and glucose-inhibited central neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
25. [Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
26. [Effects of glucose and insulin on glucokinase activity in rat hypothalamus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
27. [Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17712)
28. ensembl Release 106