# GLI-Kruppel family member GLI3

> mammalian protein found in Mus musculus

**Wikidata**: [Q14886933](https://www.wikidata.org/wiki/Q14886933)  
**Source**: https://4ort.xyz/entity/gli-kruppel-family-member-gli3


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q61602)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
5. [Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
6. [GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
7. [The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
8. [WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
9. [The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
10. [Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
11. [Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
12. [Genomic organization, chromosomal assignment, and expression analysis of the mouse suppressor of fused gene (Sufu) coding a Gli protein partner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
13. [Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
14. [Centrosomal Protein DZIP1 Regulates Hedgehog Signaling by Promoting Cytoplasmic Retention of Transcription Factor GLI3 and Affecting Ciliogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
15. [Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61602&geneProductId=UniProtKB:Q61602)
17. [Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
18. [Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
19. [Functional characterization of putative cilia genes by high-content analysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
20. [Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
21. [Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
22. [Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
23. [Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
24. [Analysis of early ventral telencephalic defects in mice lacking functional Gli3 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
25. [Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
26. [Complementary Gli activity mediates early patterning of the mouse visual system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
27. [Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
28. [Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
29. [Anorectal malformations caused by defects in sonic hedgehog signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
30. [Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
31. [Specific requirements of sonic hedgehog signaling during oligodendrocyte development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
32. [Gli3-mediated repression of Hedgehog targets is required for normal mammary development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
33. [The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
34. [PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
35. [Gli3 null mice display glandular overgrowth of the developing stomach](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
36. [A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
37. [Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
38. [Apoptotic degeneration in the arhinencephalic brain of the mouse mutant Pdn/Pdn](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
39. [The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
40. [Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
41. [Haploinsufficient Phenotypes inBmp4Heterozygous Null Mice and Modification by Mutations inGli3andAlx4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
42. [Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
43. [Evidence for the Involvement of theGliGene Family in Embryonic Mouse Lung Development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
44. [Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
45. [Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
46. [A crucial role for primary cilia in cortical morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
47. [Limb anterior–posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
48. [Hoxd and Gli3 interactions modulate digit number in the amniote limb](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
49. [Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)
50. [A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602)