# GLI family zinc finger 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5513621](https://www.wikidata.org/wiki/Q5513621)  
**Source**: https://4ort.xyz/entity/gli-family-zinc-finger-3


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P10071)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
5. [GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
6. [Characterization of the interactions of human ZIC3 mutants with GLI3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
7. [Mediator modulates Gli3-dependent Sonic hedgehog signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10071&geneProductId=UniProtKB:P10071)
9. [Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
10. [CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
11. [GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
12. [Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
13. [Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
14. [Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
15. [WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
16. [The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
17. [Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
18. [Physical and functional interactions between Zic and Gli proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
19. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
20. [Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
21. [Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
22. [Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
23. [Gli regulation by the opposing activities of fused and suppressor of fused](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
24. [Centrosomal Protein DZIP1 Regulates Hedgehog Signaling by Promoting Cytoplasmic Retention of Transcription Factor GLI3 and Affecting Ciliogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
25. [Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
26. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
27. [Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
28. [Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
29. [Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
30. [Mediator modulates Gli3-dependent Sonic hedgehog signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10071&geneProductId=UniProtKB:P10071)
31. [The sonic hedgehog-patched-gli pathway in human development and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
32. [Hydrometrocolpos, postaxial polydactyly, and hypothalamic hamartoma in a patient with confirmed Pallister-Hall syndrome: a clinical overlap with McKusick-Kaufman syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
33. [Mutation in GLI3 in postaxial polydactyly type A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
34. [Identification of the gene transcription repressor domain of Gli3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10071)
35. Ensembl Release 99
36. [STRING version 10.5](http://version-10-5.string-db.org/cgi/textmining.pl?networkId=2990w3QHfsGm)