# G protein subunit alpha i2

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28563036](https://www.wikidata.org/wiki/Q28563036)  
**Source**: https://4ort.xyz/entity/g-protein-subunit-alpha-i2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P04897)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
6. [RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
7. [Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
8. [Exogenous myristoylated-G(i2)alpha subunits of GTP-binding proteins are mitogens following their internalization by astrocytes in culture](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
9. [Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
10. [PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl cyclase 8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
11. [G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
12. [Integrins regulate opioid receptor signaling in trigeminal ganglion neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
13. [G-protein alpha subunit isoforms couple differentially to receptors that mediate presynaptic inhibition at rat hippocampal synapses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
14. [Knockdown of Inhibitory Guanine Nucleotide Binding Protein Giα-2 by Antisense Oligodeoxynucleotides Attenuates the Development of Hypertension and Tachycardia in Spontaneously Hypertensive Rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
15. [The Essential Role of Giα2 in Prostate Cancer Cell Migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
16. [Brain heterotrimeric Gαi 2 ‐subunit protein‐gated pathways mediate central sympathoinhibition to maintain fluid and electrolyte homeostasis during stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
17. [Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
18. [Galpha(i2) enhances insulin signaling via suppression of protein-tyrosine phosphatase 1B.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
19. [Effect of G protein heterotrimer composition on coupling of neurotransmitter receptors to N-type Ca(2+) channel modulation in sympathetic neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
20. [Evidence for the involvement of Gi2 in activation of extracellular signal-regulated kinases in hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
21. [Overexpression of wild-type Galpha(i)-2 suppresses beta-adrenergic signaling in cardiac myocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
22. [Gi2 signaling enhances proliferation of neural progenitor cells in the developing brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
23. [Lysophosphatidic acid rescues bone mesenchymal stem cells from hydrogen peroxide-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04897)
24. ensembl Release 106