G protein subunit alpha i1
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P63096
additional property: PropertyValue
  property ID: P361
  value: G protein alpha subunit, helical insertion
additional property: PropertyValue
  property ID: P361
  value: G-protein alpha subunit, group I
additional property: PropertyValue
  property ID: P361
  value: P-loop containing nucleoside triphosphate hydrolase
additional property: PropertyValue
  property ID: P637
  value: NP_001243343
additional property: PropertyValue
  property ID: P637
  value: NP_002060
additional property: PropertyValue
  property ID: P638
  value: 1KJY
additional property: PropertyValue
  property ID: P638
  value: 1Y3A
additional property: PropertyValue
  property ID: P638
  value: 2G83
additional property: PropertyValue
  property ID: P680
  value: GTPase activating protein binding
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: G-protein beta/gamma-subunit complex binding
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: centrosome
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P682
  value: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
additional property: PropertyValue
  property ID: P682
  value: adenylate cyclase-modulating G protein-coupled receptor signaling pathway
additional property: PropertyValue
  property ID: P682
  value: response to peptide hormone
additional property: PropertyValue
  property ID: P702
  value: GNAI1
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000343027
additional property: PropertyValue
  property ID: P705
  value: ENSP00000410572
additional property: PropertyValue
  property ID: P705
  value: ENSP00000388347
additional property: PropertyValue
  property ID: P2888
  value: https://identifiers.org/uniprot:P63096
additional property: PropertyValue
  property ID: P2888
  value: http://purl.uniprot.org/uniprot/P63096
additional property: PropertyValue
  property ID: P2888
  value: https://www.ncbi.nlm.nih.gov/protein/P63096
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 25
      unique citations norm: 0.01
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 25
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P63096
    source count: 1
    confidence: 0.2
  P361:
    value: Q24776976
    source count: 1
    confidence: 0.2
    value label: G protein alpha subunit, helical insertion
  P361:
    value: Q24719569
    source count: 1
    confidence: 0.2
    value label: G-protein alpha subunit, group I
  P361:
    value: Q24726930
    source count: 1
    confidence: 0.2
    value label: P-loop containing nucleoside triphosphate hydrolase
  P637:
    value: NP_001243343
    source count: 1
    confidence: 0.2
  P637:
    value: NP_002060
    source count: 1
    confidence: 0.2
  P638:
    value: 1KJY
    source count: 1
    confidence: 0.2
  P638:
    value: 1Y3A
    source count: 1
    confidence: 0.2
  P638:
    value: 2G83
    source count: 1
    confidence: 0.2
  P638:
    value: 2GTP
    source count: 1
    confidence: 0.2
  P638:
    value: 2IK8
    source count: 1
    confidence: 0.2
  P680:
    value: Q14908108
    source count: 1
    confidence: 0.2
    value label: GTPase activating protein binding
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding
  P680:
    value: Q14888542
    source count: 2
    confidence: 0.4
    value label: G-protein beta/gamma-subunit complex binding
  P680:
    value: Q14907895
    source count: 2
    confidence: 0.4
    value label: GDP binding
  P680:
    value: Q21103233
    source count: 2
    confidence: 0.4
    value label: G protein-coupled serotonin receptor binding
  P681:
    value: Q79899
    source count: 3
    confidence: 0.6
    value label: cytoplasm
  P681:
    value: Q190769
    source count: 3
    confidence: 0.6
    value label: centrosome
  P681:
    value: Q14349455
    source count: 2
    confidence: 0.4
    value label: membrane
  P681:
    value: Q29548
    source count: 8
    confidence: 1.0
    value label: plasma membrane
  P681:
    value: Q3824358
    source count: 1
    confidence: 0.2
    value label: intracellular anatomical structure

value: Q14864081
source count: 1
confidence: 0.2
value label: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

value: Q14821396
source count: 2
confidence: 0.4
value label: adenylate cyclase-modulating G protein-coupled receptor signaling pathway

value: Q14820890
source count: 1
confidence: 0.2
value label: response to peptide hormone

value: Q14864043
source count: 1
confidence: 0.2
value label: negative regulation of synaptic transmission

value: Q188909
source count: 2
confidence: 0.4
value label: cell division

value: Q18026220
source count: 1
confidence: 0.2
value label: GNAI1

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000343027
source count: 1
confidence: 0.2

value: ENSP00000410572
source count: 1
confidence: 0.2

value: ENSP00000388347
source count: 1
confidence: 0.2

value: ENSP00000389435
source count: 1
confidence: 0.2

value: ENSP00000391439
source count: 1
confidence: 0.2

value: https://identifiers.org/uniprot:P63096
source count: 1
confidence: 0.2

value: http://purl.uniprot.org/uniprot/P63096
source count: 1
confidence: 0.2

value: https://www.ncbi.nlm.nih.gov/protein/P63096
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2017-10-31

source: Structural diversity in the RGS domain and its interaction with heterotrimeric G protein -subunits
stated in qid: Q27650447
retrieved: 2019-04-08

source: Crystal structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Gαi
stated in qid: Q28115003
retrieved: 2019-04-08

source: A proteome-scale map of the human interactome network
stated in qid: Q24307146
retrieved: 2019-04-08

source: Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
stated in qid: Q24313402
retrieved: 2019-04-08

source: Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs
stated in qid: Q28116834
retrieved: 2019-04-08

source: Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.
stated in qid: Q24320069
retrieved: 2019-04-08

source: GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin
stated in qid: Q28115671
retrieved: 2019-04-08

source: SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex
stated in qid: Q40036318
retrieved: 2019-04-08

source: Cortical dynein is critical for proper spindle positioning in human cells
stated in qid: Q24300064
retrieved: 2019-04-08

source: Integral and associated lysosomal membrane proteins
stated in qid: Q24295014
retrieved: 2017-10-31

source: Human cDNA clones for an alpha subunit of Gi signal-transduction protein
stated in qid: Q24569662
retrieved: 2017-10-31

source: Large-scale proteomics and phosphoproteomics of urinary exosomes
stated in qid: Q24321631
retrieved: 2017-10-31

source: Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation
stated in qid: Q29871463
retrieved: 2019-04-08

source: Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase
stated in qid: Q29871470
retrieved: 2019-04-08

source: Integral and associated lysosomal membrane proteins
stated in qid: Q24295014
retrieved: 2019-04-08

source: Human cDNA clones for an alpha subunit of Gi signal-transduction protein
stated in qid: Q24569662
retrieved: 2019-04-08

source: Large-scale proteomics and phosphoproteomics of urinary exosomes
stated in qid: Q24321631
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: Identifiers.org
stated in qid: Q16335163

source: UniProt
stated in qid: Q905695
retrieved: 2018-07-18

source: Q20641742
stated in qid: Q20641742
retrieved: 2018-05-18

source: ensembl Release 93
stated in qid: Q55909277

wikidata id: Q21106184
domain: protein
level: standard
html url: https://4ort.xyz/entity/g-protein-subunit-alpha-i1
markdown url: https://4ort.xyz/entity/g-protein-subunit-alpha-i1.md
facts url summary: https://4ort.xyz/entity/g-protein-subunit-alpha-i1/facts.json
facts url standard: https://4ort.xyz/entity/g-protein-subunit-alpha-i1/facts.json
facts url full: https://4ort.xyz/entity/g-protein-subunit-alpha-i1/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T10:35:55.558294Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:47:25.717321+00:00Z