G protein subunit alpha 12
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: G protein alpha subunit, helical insertion
additional property: PropertyValue
  property ID: P361
  value: G-protein alpha subunit, group 12/13
additional property: PropertyValue
  property ID: P361
  value: P-loop containing nucleoside triphosphate hydrolase
additional property: PropertyValue
  property ID: P637
  value: NP_001269369
additional property: PropertyValue
  property ID: P637
  value: NP_001269370
additional property: PropertyValue
  property ID: P637
  value: NP_001280021
additional property: PropertyValue
  property ID: P638
  value: 1ZCA
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: GTP binding
additional property: PropertyValue
  property ID: P680
  value: metal ion binding
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: focal adhesion
additional property: PropertyValue
  property ID: P681
  value: heterotrimeric G-protein complex
additional property: PropertyValue
  property ID: P682
  value: cell differentiation
additional property: PropertyValue
  property ID: P682
  value: intracellular signal transduction
additional property: PropertyValue
  property ID: P682
  value: regulation of TOR signaling
additional property: PropertyValue
  property ID: P702
  value: GNA12
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000275364
additional property: PropertyValue
  property ID: P705
  value: ENSP00000385935
additional property: PropertyValue
  property ID: P705
  value: ENSP00000386054
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 15
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 15
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q03113
    source count: 1
    confidence: 0.2
  P361:
    value: Q24776976
    source count: 1
    confidence: 0.2
    value label: G protein alpha subunit, helical insertion
  P361:
    value: Q24767056
    source count: 1
    confidence: 0.2
    value label: G-protein alpha subunit, group 12/13
  P361:
    value: Q24726930
    source count: 1
    confidence: 0.2
    value label: P-loop containing nucleoside triphosphate hydrolase
  P637:
    value: NP_001269369
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001269370
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001280021
    source count: 1
    confidence: 0.2
  P637:
    value: NP_031379
    source count: 1
    confidence: 0.2
  P638:
    value: 1ZCA
    source count: 1
    confidence: 0.2
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding
  P680:
    value: Q14863341
    source count: 1
    confidence: 0.2
    value label: GTP binding
  P680:
    value: Q13667380
    source count: 1
    confidence: 0.2
    value label: metal ion binding
  P680:
    value: Q167149
    source count: 2
    confidence: 0.4
    value label: protein binding
  P680:
    value: Q21138074
    source count: 1
    confidence: 0.2
    value label: guanyl nucleotide binding
  P681:
    value: Q14349455
    source count: 1
    confidence: 0.2
    value label: membrane
  P681:
    value: Q904514
    source count: 1
    confidence: 0.2
    value label: focal adhesion
  P681:
    value: Q14905146
    source count: 1
    confidence: 0.2
    value label: heterotrimeric G-protein complex
  P681:
    value: Q14884512
    source count: 2
    confidence: 0.4
    value label: brush border membrane
  P681:
    value: Q79899
    source count: 1
    confidence: 0.2
    value label: cytoplasm
  P682:
    value: Q210861
    source count: 1
    confidence: 0.2
    value label: cell differentiation
  P682:
    value: Q14851952
    source count: 1
    confidence: 0.2
    value label: intracellular signal transduction
  P682:
    value: Q21101379
    source count: 2
    confidence: 0.4
    value label: regulation of TOR signaling
  P682:
    value: Q14821396
    source count: 1
    confidence: 0.2
    value label: adenylate cyclase-modulating G protein-coupled receptor signaling pathway
  P682:
    value: Q14865044
    source count: 1
    confidence: 0.2
    value label: small GTPase mediated signal transduction

value: Q18026214
source count: 1
confidence: 0.2
value label: GNA12

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000275364
source count: 1
confidence: 0.2

value: ENSP00000385935
source count: 1
confidence: 0.2

value: ENSP00000386054
source count: 1
confidence: 0.2

value: ENSP00000391462
source count: 1
confidence: 0.2

source: Swiss-Prot
stated in qid: Q2629752
retrieved: 2015-11-09

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho
stated in qid: Q22008793
retrieved: 2019-04-08

source: RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits
stated in qid: Q33360197
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2017-10-31

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets
stated in qid: Q24336496
retrieved: 2017-10-31

source: G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets
stated in qid: Q24336496
retrieved: 2019-04-08

source: Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation
stated in qid: Q24297812
retrieved: 2017-10-31

source: Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation
stated in qid: Q24297812
retrieved: 2019-04-08

source: PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12
stated in qid: Q24323912
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21106187
domain: protein
level: standard
html url: https://4ort.xyz/entity/g-protein-subunit-alpha-12
markdown url: https://4ort.xyz/entity/g-protein-subunit-alpha-12.md
facts url summary: https://4ort.xyz/entity/g-protein-subunit-alpha-12/facts.json
facts url standard: https://4ort.xyz/entity/g-protein-subunit-alpha-12/facts.json
facts url full: https://4ort.xyz/entity/g-protein-subunit-alpha-12/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T11:40:02.036532Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:58:50.900290+00:00Z