# G protein-coupled receptor kinase 2 Dmel_CG17998

> protein found in Drosophila melanogaster

**Wikidata**: [Q29814015](https://www.wikidata.org/wiki/Q29814015)  
**Source**: https://4ort.xyz/entity/g-protein-coupled-receptor-kinase-2-dmel-cg17998


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P32866)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866)
5. [Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866)
6. [Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866)
7. [G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866)
8. [PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866)
9. [The Drosophila G-protein-coupled receptor kinase homologue Gprk2 is required for egg morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866)
10. [Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866)
11. [Gprk2 adjusts Fog signaling to organize cell movements in Drosophila gastrulation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866)
12. [Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866)
13. [Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866)
14. [The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866)
15. [Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866)
16. [Regulation of smoothened by Drosophila G-protein-coupled receptor kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866)
17. ensembl Release 106