# Fyn proto-oncogene

> mammalian protein found in Mus musculus

**Wikidata**: [Q21984751](https://www.wikidata.org/wiki/Q21984751)  
**Source**: https://4ort.xyz/entity/fyn-proto-oncogene


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P39688)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
5. [Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
6. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
7. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P39688)
8. [Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
9. [HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
10. [Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
11. [Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
12. [Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
13. [Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
14. [Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
15. [Molecular cloning of Fyn-associated molecules in the mouse central nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
16. [Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
17. ['Srcasm: a Novel SrcActivating and SignalingMolecule](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
18. [Diversity Revealed by a Novel Family of Cadherins Expressed in Neurons at a Synaptic Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
19. [Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
20. [Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
21. [IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
22. [Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
23. [Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
24. [A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
25. [Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
26. [Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
27. [Bioinformatics and cellular signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
28. [Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
29. [The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
30. [Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
31. [GPRC5B activates obesity-associated inflammatory signaling in adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
32. [Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P39688)
33. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39688&geneProductId=UniProtKB:P39688)
34. [Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39688&geneProductId=UniProtKB:P39688)
35. [Phosphorylation of the antiviral protein interferon-inducible transmembrane protein 3 (IFITM3) dually regulates its endocytosis and ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39688&geneProductId=UniProtKB:P39688)
36. [Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39688&geneProductId=UniProtKB:P39688)
37. [Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39688&geneProductId=UniProtKB:P39688)
38. [Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39688&geneProductId=UniProtKB:P39688)
39. [Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39688&geneProductId=UniProtKB:P39688)
40. [CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39688&geneProductId=UniProtKB:P39688)
41. [Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39688&geneProductId=UniProtKB:P39688)
42. [Phosphorylation of the antiviral protein interferon-inducible transmembrane protein 3 (IFITM3) dually regulates its endocytosis and ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
43. [CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
44. [Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
45. [Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
46. [The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
47. [Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39688&geneProductId=UniProtKB:P39688)
48. [Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
49. [Redox-Induced Src Kinase and Caveolin-1 Signaling in TGF-β1-Initiated SMAD2/3 Activation and PAI-1 Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)
50. [Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39688)