# FYN proto-oncogene, Src family tyrosine kinase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q423628](https://www.wikidata.org/wiki/Q423628)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/FYN)  
**Source**: https://4ort.xyz/entity/fyn-proto-oncogene-src-family-tyrosine-kinase


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P06241)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
6. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241)
7. [Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241)
8. [Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
9. [ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
10. [The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
11. [Unc119, a novel activator of Lck/Fyn, is essential for T cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
12. [Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
13. [Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
14. [Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
15. [SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
16. [Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
17. [Tau interacts with src-family non-receptor tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
18. [UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
19. [Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
20. [Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
21. [Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
22. [Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
23. [Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
24. [Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
25. [Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
26. [Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
27. [The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
28. [Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
29. [Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
30. [Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
31. [Regulation of FynT function by dual domain docking on PAG/Cbp](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
32. [FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
33. [Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
34. [EG-1 interacts with c-Src and activates its signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
35. [Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
36. [Physical and functional interaction between protein kinase C delta and Fyn tyrosine kinase in human platelets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
37. [p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
38. [Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
39. [Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
40. [Platelet-derived growth factor receptor sequences important for binding of src family tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
41. [Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
42. [Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
43. [Phospho-tyrosine dependent protein-protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
44. [Direct interaction in T-cells between thetaPKC and the tyrosine kinase p59fyn](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
45. [Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
46. [Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
47. [Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
48. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
49. [A novel, non-immunogenic Fyn SH3-derived binding protein with tumor vascular targeting properties](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)
50. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241)