# Fused Dmel_CG6551

> protein found in Drosophila melanogaster

**Wikidata**: [Q29815568](https://www.wikidata.org/wiki/Q29815568)  
**Source**: https://4ort.xyz/entity/fused-dmel-cg6551


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P23647)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647)
6. [Protein kinases and phosphatases in the Drosophila genome](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647)
7. [A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647)
8. [Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647)
9. [The Fused/Smurf Complex Controls the Fate of Drosophila Germline Stem Cells by Generating a Gradient BMP Response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
10. [The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
11. [Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
12. [G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
13. [Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
14. [The sex determination master switch, Sex-lethal, responds to Hedgehog signaling in the Drosophila germline](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
15. [A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
16. [The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
17. [Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
18. [The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
20. [The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
21. [Identification of a tetrameric hedgehog signaling complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
22. [Suppressor of fused links Fused and Cubitus interruptus on the Hedgehog signalling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
23. [Regulation of Hedgehog signaling: a complex story](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647)
24. [The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647)
25. [The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647)
26. [Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647)
27. [Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647)
28. [Germ cell development in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647)
29. [Fused-dependent Hedgehog signal transduction is required for somatic cell differentiation during Drosophila egg chamber formation.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647)
30. [Mutations affecting segment number and polarity in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
31. [Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647)
32. [Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
33. [Cilia-mediated hedgehog signaling in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
34. [Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647)
35. [The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647)
36. [Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647)
37. [The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647)
38. [Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647)
39. [Fused-dependent Hedgehog signal transduction is required for somatic cell differentiation during Drosophila egg chamber formation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
40. [Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
41. [Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
42. [Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
43. [Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
44. [Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
45. [The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
46. [The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647)
47. ensembl Release 106