# Furin, paired basic amino acid cleaving enzyme

> mammalian protein found in Homo sapiens

**Wikidata**: [Q581324](https://www.wikidata.org/wiki/Q581324)  
**Source**: https://4ort.xyz/entity/furin-paired-basic-amino-acid-cleaving-enzyme


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P09958)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
6. [Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
8. [Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
9. [Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
10. [Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
11. [Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
12. [Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
13. [Furin Functions as a Nonproteolytic Chaperone for Matrix Metalloproteinase-28: MMP-28 Propeptide Sequence Requirement](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
14. [Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
15. [Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
16. [K153R polymorphism in myostatin gene increases the rate of promyostatin activation by furin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
17. [The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
18. [The shedding activity of ADAM17 is sequestered in lipid rafts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
19. [Processing of Prothyrotropin-releasing Hormone by the Family of Prohormone Convertases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958)
21. [Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958)
22. [The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958)
23. [Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958)
24. [The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958)
25. [Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
26. [The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
27. [Processing of transforming growth factor beta 1 precursor by human furin convertase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
28. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
29. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958)
30. [Cell-surface processing of pro-ADAMTS9 by furin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
31. [Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958)
32. [Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
33. [Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958)
34. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
35. [Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
36. [The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
37. [Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
38. [Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09958)
39. [Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958)
40. [Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958)
41. [Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958)
42. [Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958)
43. [Processing of Prothyrotropin-releasing Hormone by the Family of Prohormone Convertases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09958&geneProductId=UniProtKB:P09958)
44. Ensembl Release 99
45. Identifiers.org
46. UMLS 2023