Frizzled class receptor 4
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: Klaus Teuber
additional property: PropertyValue
  property ID: P361
  value: Frizzled cysteine-rich domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Frizzled-4
additional property: PropertyValue
  property ID: P361
  value: membrane protein
additional property: PropertyValue
  property ID: P527
  value: frizzled domain
additional property: PropertyValue
  property ID: P527
  value: GPCR, family 2-like
additional property: PropertyValue
  property ID: P527
  value: Frizzled/Smoothened, transmembrane domain
additional property: PropertyValue
  property ID: P637
  value: NP_032081
additional property: PropertyValue
  property ID: P637
  value: XP_036008573
additional property: PropertyValue
  property ID: P680
  value: signal transducer activity
additional property: PropertyValue
  property ID: P680
  value: transmembrane signaling receptor activity
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P681
  value: cell-cell junction
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: plasma membrane
additional property: PropertyValue
  property ID: P682
  value: signal transduction
additional property: PropertyValue
  property ID: P682
  value: progesterone secretion
additional property: PropertyValue
  property ID: P682
  value: multicellular organism development
additional property: PropertyValue
  property ID: P702
  value: Fzd4
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000049852
confidence:
  popularity graph score:
    score: 0.004
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 30
      unique citations norm: 0.012
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 30
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q61088
    source count: 1
    confidence: 0.2
    value label: Klaus Teuber
  P361:
    value: Q41797887
    source count: 1
    confidence: 0.2
    value label: Frizzled cysteine-rich domain superfamily
  P361:
    value: Q24774894
    source count: 1
    confidence: 0.2
    value label: Frizzled-4
  P361:
    value: Q423042
    source count: 1
    confidence: 0.2
    value label: membrane protein
  P361:
    value: Q83162143
    source count: 1
    confidence: 0.2
    value label: Frizzled/Smoothened, transmembrane domain, protein family
  P361:
    value: Q83138931
    source count: 1
    confidence: 0.2
    value label: GPCR, family 2-like
  P527:
    value: Q24722437
    source count: 1
    confidence: 0.2
    value label: frizzled domain
  P527:
    value: Q24766813
    source count: 1
    confidence: 0.2
    value label: GPCR, family 2-like
  P527:
    value: Q24781298
    source count: 1
    confidence: 0.2
    value label: Frizzled/Smoothened, transmembrane domain
  P637:
    value: NP_032081
    source count: 1
    confidence: 0.2
  P637:
    value: XP_036008573
    source count: 1
    confidence: 0.2
  P680:
    value: Q14820643
    source count: 1
    confidence: 0.2
    value label: signal transducer activity
  P680:
    value: Q14864356
    source count: 1
    confidence: 0.2
    value label: transmembrane signaling receptor activity
  P680:
    value: Q167149
    source count: 7
    confidence: 1.0
    value label: protein binding
  P680:
    value: Q14860298
    source count: 2
    confidence: 0.4
    value label: PDZ domain binding
  P680:
    value: Q14762996
    source count: 2
    confidence: 0.4
    value label: protein homodimerization activity
  P681:
    value: Q14873267
    source count: 1
    confidence: 0.2
    value label: cell-cell junction
  P681:
    value: Q14349455
    source count: 2
    confidence: 0.4
    value label: membrane
  P681:
    value: Q29548
    source count: 7
    confidence: 1.0
    value label: plasma membrane
  P681:
    value: Q189094
    source count: 2
    confidence: 0.4
    value label: cell surface
  P681:
    value: Q903634
    source count: 2
    confidence: 0.4
    value label: extracellular exosome
  P682:
    value: Q828130
    source count: 1
    confidence: 0.2
    value label: signal transduction
  P682:
    value: Q21107467
    source count: 1
    confidence: 0.2
    value label: progesterone secretion

value: Q14645705
source count: 1
confidence: 0.2
value label: multicellular organism development

value: Q21095685
source count: 1
confidence: 0.2
value label: retinal blood vessel morphogenesis

value: Q14819470
source count: 1
confidence: 0.2
value label: substrate adhesion-dependent cell spreading

value: Q18250690
source count: 1
confidence: 0.2
value label: Fzd4

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000049852
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2017-09-16

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4
stated in qid: Q28588320
retrieved: 2019-05-09

source: Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.
stated in qid: Q28589685
retrieved: 2019-05-09

source: Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation
stated in qid: Q24304483
retrieved: 2019-05-09

source: MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap
stated in qid: Q28266828
retrieved: 2019-05-09

source: Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt
stated in qid: Q24314681
retrieved: 2019-05-09

source: A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.
stated in qid: Q48447275
retrieved: 2019-05-09

source: WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature
stated in qid: Q28511517
retrieved: 2017-09-16

source: Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair
stated in qid: Q24318751
retrieved: 2019-05-09

source: Wnt2b controls retinal cell differentiation at the ciliary marginal zone
stated in qid: Q24337355
retrieved: 2017-09-16

source: Wnt2b controls retinal cell differentiation at the ciliary marginal zone
stated in qid: Q24337355
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature
stated in qid: Q28511517
retrieved: 2019-05-09

source: Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation
stated in qid: Q24304483
retrieved: 2017-09-16

source: Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair
stated in qid: Q24318751
retrieved: 2017-09-16

source: Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation
stated in qid: Q46254513
retrieved: 2019-05-09

source: Mice null for Frizzled4 (Fzd4-/-) are infertile and exhibit impaired corpora lutea formation and function
stated in qid: Q28584867
retrieved: 2019-05-09

source: Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene
stated in qid: Q28586185
retrieved: 2019-05-09

source: Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization
stated in qid: Q28591418
retrieved: 2019-05-09

source: The frizzled-related sFRP2 gene is a target of thyroid hormone receptor alpha1 and activates beta-catenin signaling in mouse intestine
stated in qid: Q28509030
retrieved: 2017-09-16

source: Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation
stated in qid: Q28268464
retrieved: 2017-09-16

source: Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization
stated in qid: Q28591418
retrieved: 2017-09-16

source: miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells
stated in qid: Q30176408
retrieved: 2019-05-09

source: The frizzled-related sFRP2 gene is a target of thyroid hormone receptor alpha1 and activates beta-catenin signaling in mouse intestine
stated in qid: Q28509030
retrieved: 2019-02-14

source: Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation
stated in qid: Q28268464
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q21983268
domain: protein
level: standard
html url: https://4ort.xyz/entity/frizzled-class-receptor-4
markdown url: https://4ort.xyz/entity/frizzled-class-receptor-4.md
facts url summary: https://4ort.xyz/entity/frizzled-class-receptor-4/facts.json
facts url standard: https://4ort.xyz/entity/frizzled-class-receptor-4/facts.json
facts url full: https://4ort.xyz/entity/frizzled-class-receptor-4/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T06:03:37.835114Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:40:56.656023+00:00Z