# Frizzled class receptor 4

> mammalian protein found in Mus musculus

**Wikidata**: [Q21983268](https://www.wikidata.org/wiki/Q21983268)  
**Source**: https://4ort.xyz/entity/frizzled-class-receptor-4


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q61088)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61088&geneProductId=UniProtKB:Q61088)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
6. [Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
7. [Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
8. [Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
9. [MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
10. [Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
11. [A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
12. [WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61088&geneProductId=UniProtKB:Q61088)
13. [Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
14. [Wnt2b controls retinal cell differentiation at the ciliary marginal zone](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61088&geneProductId=UniProtKB:Q61088)
15. [Wnt2b controls retinal cell differentiation at the ciliary marginal zone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
17. [WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
18. [Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61088&geneProductId=UniProtKB:Q61088)
19. [Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61088&geneProductId=UniProtKB:Q61088)
20. [Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
21. [Mice null for Frizzled4 (Fzd4-/-) are infertile and exhibit impaired corpora lutea formation and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
22. [Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
23. [Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
24. [The frizzled-related sFRP2 gene is a target of thyroid hormone receptor alpha1 and activates beta-catenin signaling in mouse intestine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61088&geneProductId=UniProtKB:Q61088)
25. [Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61088&geneProductId=UniProtKB:Q61088)
26. [Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61088&geneProductId=UniProtKB:Q61088)
27. [miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
28. [The frizzled-related sFRP2 gene is a target of thyroid hormone receptor alpha1 and activates beta-catenin signaling in mouse intestine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
29. [Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61088)
30. ensembl Release 106