# Frizzled class receptor 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21115948](https://www.wikidata.org/wiki/Q21115948)  
**Source**: https://4ort.xyz/entity/frizzled-class-receptor-4-q21115948


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9ULV1)
3. Q20641742
4. [Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1)
5. [Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1)
6. [Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1)
7. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1)
8. [Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1)
9. [Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1)
10. [TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1)
11. [Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1)
12. [ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1)
14. [Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1)
15. [A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1)
17. [Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1)
18. [Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1)
19. [Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1)
20. [Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1)
21. [A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1)
22. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1)
23. [Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1)
24. [Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1)
25. [Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1)
26. [Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1)
27. [Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q.](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1)
28. [Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1)
29. Ensembl Release 99
30. Identifiers.org