# Forkhead box O3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21101484](https://www.wikidata.org/wiki/Q21101484)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/FOXO3)  
**Source**: https://4ort.xyz/entity/forkhead-box-o3


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O43524)
3. Q20641742
4. [Functional interaction between beta-catenin and FOXO in oxidative stress signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
6. [A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
7. [Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
8. [Deficiency of the Transcriptional Regulator p8 Results in Increased Autophagy and Apoptosis, and Causes Impaired Heart Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
9. [CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
10. [IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
11. [Bimodal regulation of FoxO3 by AKT and 14-3-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
12. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
13. [The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
14. [FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
15. [Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
16. [Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
17. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
18. [14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
19. [Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
20. [The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
21. [Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
22. [c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
23. [Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
24. [A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
25. [The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
26. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524)
27. [FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524)
28. [Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524)
29. [Foxo3a regulates apoptosis by negatively targeting miR-21](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
30. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524)
31. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
32. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
33. [FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
34. [Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
35. [IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524)
36. [A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524)
37. [A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524)
38. [The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524)
39. [Foxo3a regulates apoptosis by negatively targeting miR-21](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524)
40. [Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524)
41. [CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524)
42. [Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524)
43. [Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524)
44. [Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
45. [BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43524&geneProductId=UniProtKB:O43524)
46. [Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
47. [BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43524)
48. Ensembl Release 99
49. UMLS 2023
50. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)