# Forkhead box O1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21102210](https://www.wikidata.org/wiki/Q21102210)  
**Source**: https://4ort.xyz/entity/forkhead-box-o1-q21102210


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q12778)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12778&geneProductId=UniProtKB:Q12778)
5. [Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12778&geneProductId=UniProtKB:Q12778)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
7. [Functional interaction between beta-catenin and FOXO in oxidative stress signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
8. [Novel repressor regulates insulin sensitivity through interaction with Foxo1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
9. [Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
10. [The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
11. [Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
12. [Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
13. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
14. [CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
15. [DBC1 is a negative regulator of SIRT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
16. [Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
17. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
18. [Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
19. [Inhibition of FoxO1 acetylation by INHAT subunit SET/TAF‐Iβ induces p21 transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
20. [Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
21. [APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
22. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
24. [Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
25. [The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12778&geneProductId=UniProtKB:Q12778)
26. [Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12778&geneProductId=UniProtKB:Q12778)
27. [Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12778&geneProductId=UniProtKB:Q12778)
28. [GAS6-induced signaling in human endothelial cells is mediated by FOXO1a](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12778&geneProductId=UniProtKB:Q12778)
29. [GAS6-induced signaling in human endothelial cells is mediated by FOXO1a](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
30. [The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
31. [Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
32. [The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
33. [FoxM1, a critical regulator of oxidative stress during oncogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12778)
34. [Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12778&geneProductId=UniProtKB:Q12778)
35. Ensembl Release 99
36. UMLS 2023