# Forkhead box C1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116910](https://www.wikidata.org/wiki/Q21116910)  
**Source**: https://4ort.xyz/entity/forkhead-box-c1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q12948)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
5. [FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
6. [Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
7. [Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
8. [The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
9. [Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
10. [Global landscape of HIV-human protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
11. [Human p32 is a novel FOXC1-interacting protein that regulates FOXC1 transcriptional activity in ocular cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
12. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
14. [Structural and functional analyses of disease-causing missense mutations in the forkhead domain of FOXC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
15. [FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
16. [Severe molecular defects of a novel FOXC1 W152G mutation result in aniridia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
17. [Analyses of a novel L130F missense mutation in FOXC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
18. [Characterization of a novel FOXC1 mutation, P297S, identified in two individuals with anterior segment dysgenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
19. [Hypo- and hypermorphic FOXC1 mutations in dominant glaucoma: transactivation and phenotypic variability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
20. [Identification and Analysis of a Novel Mutation in the FOXC1 Forkhead Domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
21. [Comparison of Bioinformatics Prediction, Molecular Modeling, and Functional Analyses of FOXC1 Mutations in Patients with Axenfeld-Rieger Syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
22. [FOXC1 Transcriptional Regulation Is Mediated by N- and C-terminal Activation Domains and Contains a Phosphorylated Transcriptional Inhibitory Domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
23. [Essential structural and functional determinants within the forkhead domain of FOXC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
24. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
25. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
26. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
27. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
28. [Characterization of a novel FOXC1 mutation, P297S, identified in two individuals with anterior segment dysgenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
29. [Structural and functional analyses of disease-causing missense mutations in the forkhead domain of FOXC1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
30. [FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
31. [Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
32. [Identification and Analysis of a Novel Mutation in the FOXC1 Forkhead Domain](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
33. [Analyses of a novel L130F missense mutation in FOXC1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
34. [The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
35. [Comparison of Bioinformatics Prediction, Molecular Modeling, and Functional Analyses of FOXC1 Mutations in Patients with Axenfeld-Rieger Syndrome](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
36. [Severe molecular defects of a novel FOXC1 W152G mutation result in aniridia](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
37. [Hypo- and hypermorphic FOXC1 mutations in dominant glaucoma: transactivation and phenotypic variability](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
38. [FOXC1 Transcriptional Regulation Is Mediated by N- and C-terminal Activation Domains and Contains a Phosphorylated Transcriptional Inhibitory Domain](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
39. [FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
40. [Essential structural and functional determinants within the forkhead domain of FOXC1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
41. [Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
42. [The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
43. [Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948)
44. [FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
45. [The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
46. [Mutations of the forkhead/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomaly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
47. [A family with Axenfeld-Rieger syndrome and Peters Anomaly caused by a point mutation (Phe112Ser) in the FOXC1 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
48. [Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
49. [DSCAM, a highly conserved gene in mammals, expressed in differentiating mouse brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)
50. [Expression of the Mf1 gene in developing mouse hearts: implication in the development of human congenital heart defects](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948)