# Folliculin

> mammalian protein found in Mus musculus

**Wikidata**: [Q21495727](https://www.wikidata.org/wiki/Q21495727)  
**Source**: https://4ort.xyz/entity/folliculin


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8QZS3)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3)
5. [Exit from Pluripotency Is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8QZS3&geneProductId=UniProtKB:Q8QZS3)
7. [The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3)
8. [Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3)
9. [Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3)
10. [Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3)
11. [Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3)
12. [Loss of the Birt–Hogg–Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3)
13. [Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3)
14. [Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3)
15. [Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3)
16. [The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3)
17. [Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8QZS3&geneProductId=UniProtKB:Q8QZS3)
18. [Loss of the Birt–Hogg–Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8QZS3&geneProductId=UniProtKB:Q8QZS3)
19. [Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3)
20. [Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3)
21. ensembl Release 106