# fms related receptor tyrosine kinase 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21118353](https://www.wikidata.org/wiki/Q21118353)  
**Source**: https://4ort.xyz/entity/fms-related-receptor-tyrosine-kinase-4-q21118353


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL502835)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545396)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL377300)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2010872)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1278146)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2220486)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL406381)
10. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P35916)
11. Q20641742
12. [Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916)
13. [Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916)
14. [Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916)
16. [VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916)
17. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
18. [Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
19. [Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
20. [The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
21. [VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
22. [Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
23. [Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
24. [The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916)
25. [Biochemical characterization of two isoforms of FLT4, a VEGF receptor-related tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916)
26. [Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
27. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916)
28. [Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
29. [Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
30. [Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
31. [VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
32. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
33. [The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
34. [Biochemical characterization of two isoforms of FLT4, a VEGF receptor-related tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
35. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916)
36. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
37. [Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
38. [Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916)
39. [Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916)
40. [Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
41. [Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916)
42. Ensembl Release 99
43. UMLS 2023