# Fms related receptor tyrosine kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21115605](https://www.wikidata.org/wiki/Q21115605)  
**Source**: https://4ort.xyz/entity/fms-related-receptor-tyrosine-kinase-1


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL502835)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545396)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL377300)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2010872)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1278146)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2220486)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL406381)
10. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P17948)
11. Q20641742
12. [Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular endothelial cell growth factor (VEGF) receptor mRNAs by VEGF](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17948&geneProductId=UniProtKB:P17948)
13. [Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17948&geneProductId=UniProtKB:P17948)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17948&geneProductId=UniProtKB:P17948)
15. [The Phosphorylated 1169-Tyrosine Containing Region of Flt-1 Kinase (VEGFR-1) Is a Major Binding Site for PLCγ](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17948&geneProductId=UniProtKB:P17948)
16. [The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17948&geneProductId=UniProtKB:P17948)
17. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
18. [Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
19. [Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
20. [Interaction of the Flt-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositol 3-kinase. Mapping of a novel site involved in binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
21. [Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
22. [Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
23. [Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
24. [The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
25. [Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
26. [The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
27. [Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
28. [Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
29. [Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17948&geneProductId=UniProtKB:P17948)
30. [Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
31. [Transgenic overexpression of vascular endothelial growth factor-B isoforms by endothelial cells potentiates postnatal vessel growth in vivo and in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
32. [Characterization of the VEGF binding site on the Flt-1 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
33. [Human vascular endothelial growth factor B: characterization of recombinant isoforms and generation of neutralizing monoclonal antibodies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
34. [Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
35. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
36. [Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular endothelial cell growth factor (VEGF) receptor mRNAs by VEGF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
37. [Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
38. [The Phosphorylated 1169-Tyrosine Containing Region of Flt-1 Kinase (VEGFR-1) Is a Major Binding Site for PLCγ](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
39. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17948&geneProductId=UniProtKB:P17948)
40. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17948&geneProductId=UniProtKB:P17948)
41. [Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17948&geneProductId=UniProtKB:P17948)
42. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
43. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
44. [Vascular endothelial growth factor receptor-1 promotes migration and invasion in pancreatic carcinoma cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
45. [Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
46. [The molecular basis of VEGFR-1 signal transduction pathways in primary human monocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)
47. [Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17948&geneProductId=UniProtKB:P17948)
48. [Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17948&geneProductId=UniProtKB:P17948)
49. [Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17948&geneProductId=UniProtKB:P17948)
50. [Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948)