# Flap structure-specific endonuclease 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21154944](https://www.wikidata.org/wiki/Q21154944)  
**Source**: https://4ort.xyz/entity/flap-structure-specific-endonuclease-1-q21154944


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P39748)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
5. [Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748)
6. [The characterization of a mammalian DNA structure-specific endonuclease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
7. [Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
8. [Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
9. [Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
10. [The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
11. [Human MUS81 complexes stimulate flap endonuclease 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
12. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
13. [Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
14. [Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
15. [WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
16. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
17. [A protein domain-based interactome network for C. elegans early embryogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
18. [Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
19. [Stimulation of flap endonuclease-1 by the Bloom's syndrome protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
20. [Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
21. [Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
22. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748)
23. [Essential amino acids for substrate binding and catalysis of human flap endonuclease 1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748)
24. [Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748)
25. [Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748)
26. [Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748)
27. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
28. [Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
29. [Essential amino acids for substrate binding and catalysis of human flap endonuclease 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
30. [Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
31. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748)
32. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
33. [Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748)
34. [Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748)
35. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748)
36. Ensembl Release 99