# Filamin A

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109662](https://www.wikidata.org/wiki/Q21109662)  
**Source**: https://4ort.xyz/entity/filamin-a-q21109662


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P21333)
3. Q20641742
4. [Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
6. [FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
7. [Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
8. [Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
9. [Identification of actin-binding protein as the protein linking the membrane skeleton to glycoproteins on platelet plasma membranes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
10. [Localization of the domain of actin-binding protein that binds to membrane glycoprotein Ib and actin in human platelets](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
11. [The small GTPase RalA targets filamin to induce filopodia](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
12. [A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
13. [Ligand-sensitive binding of actin-binding protein to immunoglobulin G Fc Receptor I (FcγRI)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
14. [G protein-coupled receptors directly bind filamin A with high affinity and promote filamin phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
15. [CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
16. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
17. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
18. [Functional interaction with filamin A and intracellular Ca 2+ enhance the surface membrane expression of a small-conductance Ca 2+ -activated K + (SK2) channel](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
19. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
20. [A meckelin-filamin A interaction mediates ciliogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
21. [Evidence for multisite ligand binding and stretching of filamin by integrin and migfilin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
22. [The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
23. [A mechanism of global shape-dependent recognition and phosphorylation of filamin by protein kinase A](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
24. [Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
25. [Identification of Novel Nuclear Protein Interactions with the N-Terminal Part of Filamin A](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
26. [Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
27. [Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
28. [Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
29. [Interaction Between the μ Opioid Receptor and Filamin A Is Involved in Receptor Regulation and Trafficking](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
30. [Structural mechanism of integrin inactivation by filamin.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
31. [Filamin A regulates cell spreading and survival via beta1 integrins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
32. [LL5beta directs the translocation of filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
33. [A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
34. [FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
35. [Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
36. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
37. [Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
38. [The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
39. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
40. [Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
41. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
42. [Structure of three tandem filamin domains reveals auto-inhibition of ligand binding](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
43. [Filamin A stabilizes Fc gamma RI surface expression and prevents its lysosomal routing](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
44. [Modulation of dopamine D(2) receptor signaling by actin-binding protein (ABP-280)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
45. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
46. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
47. [A B-Myb complex containing clathrin and filamin is required for mitotic spindle function](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
48. [Cytoskeletal protein filamin A is a nucleolar protein that suppresses ribosomal RNA gene transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
49. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)
50. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333)