# Fides: Reliable trust-region optimization for parameter estimation of ordinary differential equation models

> Research article (PLoS Computational Biology, 2022) · cited 41× · AI/ML

**Wikidata**: [openalex:W4285088295](https://www.wikidata.org/wiki/openalex:W4285088295)  
**Source**: https://4ort.xyz/entity/fides-reliable-trust-region-optimization-for-parameter-estimation-of-ordinary-differential-equation-models