# fibroblast growth factor receptor 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21137668](https://www.wikidata.org/wiki/Q21137668)  
**Source**: https://4ort.xyz/entity/fibroblast-growth-factor-receptor-4-q21137668


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL502835)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1852688)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL377300)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545376)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL274654)
8. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P22455)
9. Q20641742
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455)
11. [Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455)
12. [Liver-specific activities of FGF19 require Klotho beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455)
13. [FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455)
15. [Liver-specific activities of FGF19 require Klotho beta](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455)
16. [FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455)
17. [Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455)
18. [Receptor specificity of the fibroblast growth factor family](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455)
19. [Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455)
20. [Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455)
21. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455)
22. [Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455)
23. [FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455)
24. [Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455)
25. [Receptor specificity of the fibroblast growth factor family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455)
27. [The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455)
28. [Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19-mediated down-regulation of cytochrome P450 7A1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455)
29. [Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19-mediated down-regulation of cytochrome P450 7A1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455)
30. [Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455)
31. [Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455)
32. [Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455)
33. [Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455)
34. Ensembl Release 99
35. UMLS 2023
36. Transporter Classification database