# fibroblast growth factor receptor 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5446456](https://www.wikidata.org/wiki/Q5446456)  
**Source**: https://4ort.xyz/entity/fibroblast-growth-factor-receptor-2


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL502835)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1852688)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL377300)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545376)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2220486)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL274654)
9. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P21802)
10. Q20641742
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802)
13. [Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802)
14. [Receptor specificity of the fibroblast growth factor family](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802)
15. [A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802)
16. [Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802)
17. [Nucleotide sequences at intron 6 and exon 7 junction of fibroblast growth factor receptor 2 and rapid mutational analysis in Apert syndrome](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802)
18. [Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802)
19. [Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802)
20. [Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
21. [Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
22. [Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
23. [Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
24. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
25. [Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
26. [Structural interactions of fibroblast growth factor receptor with its ligands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
27. [Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
28. [Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
29. [Inhibition of basal FGF receptor signaling by dimeric Grb2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
30. [A crystallographic snapshot of tyrosine trans-phosphorylation in action](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802)
31. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802)
32. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
33. [Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
34. [Nucleotide sequences at intron 6 and exon 7 junction of fibroblast growth factor receptor 2 and rapid mutational analysis in Apert syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
35. [A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
36. [Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
37. [Receptor specificity of the fibroblast growth factor family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
38. [Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
39. [FGF-10 and its receptor exhibit bidirectional paracrine targeting to urothelial and smooth muscle cells in the lower urinary tract](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
40. [Translocation of fibroblast growth factor-10 and its receptor into nuclei of human urothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
41. [Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802)
42. [Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802)
43. [Translocation of fibroblast growth factor-10 and its receptor into nuclei of human urothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802)
44. [FGF-10 and its receptor exhibit bidirectional paracrine targeting to urothelial and smooth muscle cells in the lower urinary tract](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21802&geneProductId=UniProtKB:P21802)
45. [Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
46. [Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
47. [Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
48. [Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21802)
49. Ensembl Release 99