Fibrinogen alpha chain
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P129
  value: fibrinolysin
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P02671
additional property: PropertyValue
  property ID: P361
  value: Fibrinogen-like, C-terminal
additional property: PropertyValue
  property ID: P361
  value: Fibrinogen alpha chain
additional property: PropertyValue
  property ID: P361
  value: Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain, protein family
additional property: PropertyValue
  property ID: P527
  value: Fibrinogen, conserved site
additional property: PropertyValue
  property ID: P527
  value: Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
additional property: PropertyValue
  property ID: P527
  value: Fibrinogen, alpha/beta/gamma chain, coiled coil domain
additional property: PropertyValue
  property ID: P637
  value: NP_000499
additional property: PropertyValue
  property ID: P637
  value: NP_068657
additional property: PropertyValue
  property ID: P638
  value: 1BBR
additional property: PropertyValue
  property ID: P638
  value: 1DM4
additional property: PropertyValue
  property ID: P638
  value: 1FPH
additional property: PropertyValue
  property ID: P680
  value: protein-macromolecule adaptor activity
additional property: PropertyValue
  property ID: P680
  value: structural molecule activity
additional property: PropertyValue
  property ID: P680
  value: metal ion binding
additional property: PropertyValue
  property ID: P681
  value: platelet alpha granule
additional property: PropertyValue
  property ID: P681
  value: extracellular vesicle
additional property: PropertyValue
  property ID: P681
  value: plasma membrane
additional property: PropertyValue
  property ID: P682
  value: hemostasis
additional property: PropertyValue
  property ID: P682
  value: negative regulation of endothelial cell apoptotic process
additional property: PropertyValue
  property ID: P682
  value: positive regulation of peptide hormone secretion
additional property: PropertyValue
  property ID: P702
  value: FGA
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000385981
additional property: PropertyValue
  property ID: P705
  value: ENSP00000478487
additional property: PropertyValue
  property ID: P705
  value: ENSP00000498441
confidence:
  popularity graph score:
    score: 0.005
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 34
      unique citations norm: 0.013
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 34
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P129:
    value: Q2619971
    source count: 1
    confidence: 0.2
    value label: fibrinolysin
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P02671
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797193
    source count: 1
    confidence: 0.2
    value label: Fibrinogen-like, C-terminal
  P361:
    value: Q43921652
    source count: 1
    confidence: 0.2
    value label: Fibrinogen alpha chain
  P361:
    value: Q83147268
    source count: 1
    confidence: 0.2
    value label: Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain, protein family
  P361:
    value: Q83137300
    source count: 1
    confidence: 0.2
    value label: Fibrinogen, alpha/beta/gamma chain, coiled coil domain, protein family
  P361:
    value: Q83145337
    source count: 1
    confidence: 0.2
    value label: Fibrinogen alpha C domain, protein family
  P527:
    value: Q24772779
    source count: 1
    confidence: 0.2
    value label: Fibrinogen, conserved site
  P527:
    value: Q24779823
    source count: 1
    confidence: 0.2
    value label: Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
  P527:
    value: Q24741493
    source count: 1
    confidence: 0.2
    value label: Fibrinogen, alpha/beta/gamma chain, coiled coil domain
  P527:
    value: Q24776335
    source count: 1
    confidence: 0.2
    value label: Fibrinogen alpha C domain
  P637:
    value: NP_000499
    source count: 1
    confidence: 0.2
  P637:
    value: NP_068657
    source count: 1
    confidence: 0.2
  P638:
    value: 1BBR
    source count: 1
    confidence: 0.2
  P638:
    value: 1DM4
    source count: 1
    confidence: 0.2
  P638:
    value: 1FPH
    source count: 1
    confidence: 0.2
  P638:
    value: 1FZA
    source count: 1
    confidence: 0.2
  P638:
    value: 1FZB
    source count: 1
    confidence: 0.2
  P680:
    value: Q14906108
    source count: 1
    confidence: 0.2
    value label: protein-macromolecule adaptor activity

value: Q14864149
source count: 2
confidence: 0.4
value label: structural molecule activity

value: Q13667380
source count: 1
confidence: 0.2
value label: metal ion binding

value: Q167149
source count: 6
confidence: 1.0
value label: protein binding

value: Q14819233
source count: 2
confidence: 0.4
value label: signaling receptor binding

value: Q14863673
source count: 1
confidence: 0.2
value label: platelet alpha granule

value: Q21097485
source count: 1
confidence: 0.2
value label: extracellular vesicle

value: Q29548
source count: 1
confidence: 0.2
value label: plasma membrane

value: Q381899
source count: 5
confidence: 1.0
value label: fibrinogen complex

value: Q14645596
source count: 3
confidence: 0.6
value label: extracellular region

value: Q487937
source count: 1
confidence: 0.2
value label: hemostasis

value: Q14912175
source count: 1
confidence: 0.2
value label: negative regulation of endothelial cell apoptotic process

value: Q14761976
source count: 1
confidence: 0.2
value label: positive regulation of peptide hormone secretion

value: Q14859855
source count: 2
confidence: 0.4
value label: protein polymerization

value: Q14880368
source count: 1
confidence: 0.2
value label: positive regulation of heterotypic cell-cell adhesion

value: Q5446444
source count: 1
confidence: 0.2
value label: FGA

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000385981
source count: 1
confidence: 0.2

value: ENSP00000478487
source count: 1
confidence: 0.2

value: ENSP00000498441
source count: 1
confidence: 0.2

source: Open Targets Platform
stated in qid: Q113138000
retrieved: 2023-08-14

source: GOA
stated in qid: Q28018111
retrieved: 2017-09-26

source: Mutations in the fibrinogen aalpha gene account for the majority of cases of congenital afibrinogenemia
stated in qid: Q22254595
retrieved: 2017-09-26

source: The role of betagamma and alphagamma complexes in the assembly of human fibrinogen
stated in qid: Q24319103
retrieved: 2017-09-26

source: Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein
stated in qid: Q24290130
retrieved: 2017-09-26

source: An investigation into the human serum "interactome"
stated in qid: Q24294835
retrieved: 2017-09-26

source: Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
stated in qid: Q24304309
retrieved: 2017-09-26

source: Secreted Kinase Phosphorylates Extracellular Proteins That Regulate Biomineralization
stated in qid: Q24321933
retrieved: 2017-09-26

source: A Single Kinase Generates the Majority of the Secreted Phosphoproteome
stated in qid: Q24338170
retrieved: 2017-09-26

source: Fibrinogen Magdeburg I: a novel variant of human fibrinogen with an amino acid exchange in the fibrinopeptide A (Aα 9, Leu→Pro)
stated in qid: Q24300243
retrieved: 2017-09-26

source: Fibrinogen interactions with ICAM-1 (CD54) regulate endothelial cell survival
stated in qid: Q22254636
retrieved: 2017-09-26

source: A mitogenic action for fibrinogen mediated through intercellular adhesion molecule-1
stated in qid: Q24309485
retrieved: 2017-09-26

source: Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets
stated in qid: Q24301979
retrieved: 2017-09-26

source: Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset
stated in qid: Q24295851
retrieved: 2017-09-26

source: Fibrinogen
stated in qid: Q28118778
retrieved: 2017-09-26

source: The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance
stated in qid: Q24297406
retrieved: 2017-09-26

source: Congenital hypofibrinogenemia: characterization of two missense mutations affecting fibrinogen assembly and secretion
stated in qid: Q24319923
retrieved: 2017-09-26

source: The human plasma proteome: a nonredundant list developed by combination of four separate sources
stated in qid: Q24304465
retrieved: 2017-09-26

source: Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
stated in qid: Q24313258
retrieved: 2017-09-26

source: Large-scale proteomics and phosphoproteomics of urinary exosomes
stated in qid: Q24321631
retrieved: 2017-09-26

source: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
stated in qid: Q24337415
retrieved: 2017-09-26

source: Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability
stated in qid: Q24315760
retrieved: 2017-09-26

source: Fibrinogen-induced endothelin-1 production from endothelial cells
stated in qid: Q24336335
retrieved: 2017-09-26

source: Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway
stated in qid: Q24322038
retrieved: 2017-09-26

source: The role of fibrin matrices and tissue factor in early-term trophoblast proliferation and spreading
stated in qid: Q24336393
retrieved: 2017-09-26

source: Fibrinogen and fragment D-induced vascular constriction
stated in qid: Q24297152
retrieved: 2017-09-26

source: The dysfibrinogenaemias
stated in qid: Q24291625
retrieved: 2017-09-26

source: Platelet Proteome Analysis Reveals Integrin-dependent Aggregation Defects in Patients with Myelodysplastic Syndromes
stated in qid: Q24314265
retrieved: 2017-09-26

source: gamma and alpha chains of human fibrinogen possess sites reactive with human platelet receptors
stated in qid: Q24301146
retrieved: 2017-09-26

source: The Staphylococcus aureus ArlRS two-component system is a novel regulator of agglutination and pathogenesis
stated in qid: Q24316182
retrieved: 2017-09-26

wikidata id: Q21151082
domain: protein
level: standard
html url: https://4ort.xyz/entity/fibrinogen-alpha-chain
markdown url: https://4ort.xyz/entity/fibrinogen-alpha-chain.md
facts url summary: https://4ort.xyz/entity/fibrinogen-alpha-chain/facts.json
facts url standard: https://4ort.xyz/entity/fibrinogen-alpha-chain/facts.json
facts url full: https://4ort.xyz/entity/fibrinogen-alpha-chain/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T06:55:35.637562Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:58:50.900290+00:00Z