# Fibrinogen alpha chain

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21151082](https://www.wikidata.org/wiki/Q21151082)  
**Source**: https://4ort.xyz/entity/fibrinogen-alpha-chain


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1201505)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P02671)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
6. [Mutations in the fibrinogen aalpha gene account for the majority of cases of congenital afibrinogenemia](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
7. [The role of betagamma and alphagamma complexes in the assembly of human fibrinogen](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
8. [Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
9. [An investigation into the human serum "interactome"](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
10. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
11. [Secreted Kinase Phosphorylates Extracellular Proteins That Regulate Biomineralization](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
12. [A Single Kinase Generates the Majority of the Secreted Phosphoproteome](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
13. [Fibrinogen Magdeburg I: a novel variant of human fibrinogen with an amino acid exchange in the fibrinopeptide A (Aα 9, Leu→Pro)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
14. [Fibrinogen interactions with ICAM-1 (CD54) regulate endothelial cell survival](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
15. [A mitogenic action for fibrinogen mediated through intercellular adhesion molecule-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
16. [Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
17. [Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
18. [Fibrinogen](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
19. [The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
20. [Congenital hypofibrinogenemia: characterization of two missense mutations affecting fibrinogen assembly and secretion](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
21. [The human plasma proteome: a nonredundant list developed by combination of four separate sources](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
22. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
23. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
24. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
25. [Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
26. [Fibrinogen-induced endothelin-1 production from endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
27. [Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
28. [The role of fibrin matrices and tissue factor in early-term trophoblast proliferation and spreading](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
29. [Fibrinogen and fragment D-induced vascular constriction](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
30. [The dysfibrinogenaemias](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
31. [Platelet Proteome Analysis Reveals Integrin-dependent Aggregation Defects in Patients with Myelodysplastic Syndromes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
32. [gamma and alpha chains of human fibrinogen possess sites reactive with human platelet receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
33. [The Staphylococcus aureus ArlRS two-component system is a novel regulator of agglutination and pathogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02671&geneProductId=UniProtKB:P02671)
34. Ensembl Release 99