FGR proto-oncogene, Src family tyrosine kinase
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P09769
additional property: PropertyValue
  property ID: P361
  value: SH3-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Protein kinase-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: SH2 domain superfamily
additional property: PropertyValue
  property ID: P527
  value: tyrosine-protein kinase, active site
additional property: PropertyValue
  property ID: P527
  value: protein kinase domain
additional property: PropertyValue
  property ID: P527
  value: protein kinase, ATP binding site
additional property: PropertyValue
  property ID: P637
  value: NP_001036194
additional property: PropertyValue
  property ID: P637
  value: NP_001036212
additional property: PropertyValue
  property ID: P637
  value: NP_005239
additional property: PropertyValue
  property ID: P680
  value: transferase activity
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: protein kinase activity
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: cytosol
additional property: PropertyValue
  property ID: P681
  value: cell projection
additional property: PropertyValue
  property ID: P682
  value: cell differentiation
additional property: PropertyValue
  property ID: P682
  value: regulation of innate immune response
additional property: PropertyValue
  property ID: P682
  value: Fc-gamma receptor signaling pathway involved in phagocytosis
additional property: PropertyValue
  property ID: P702
  value: FGR
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000363115
additional property: PropertyValue
  property ID: P705
  value: ENSP00000363116
additional property: PropertyValue
  property ID: P705
  value: ENSP00000363117
confidence:
  popularity graph score:
    score: 0.004
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 28
      unique citations norm: 0.011
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 28
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P09769
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797170
    source count: 1
    confidence: 0.2
    value label: SH3-like domain superfamily
  P361:
    value: Q24726164
    source count: 1
    confidence: 0.2
    value label: Protein kinase-like domain superfamily
  P361:
    value: Q41797956
    source count: 1
    confidence: 0.2
    value label: SH2 domain superfamily
  P361:
    value: Q50261758
    source count: 0
    confidence: 0.0
    value label: Src family kinases (SFKs) [cytosol]
  P361:
    value: Q83137014
    source count: 1
    confidence: 0.2
    value label: Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family
  P527:
    value: Q24738472
    source count: 1
    confidence: 0.2
    value label: tyrosine-protein kinase, active site
  P527:
    value: Q24768234
    source count: 1
    confidence: 0.2
    value label: protein kinase domain
  P527:
    value: Q24769051
    source count: 1
    confidence: 0.2
    value label: protein kinase, ATP binding site
  P527:
    value: Q24780316
    source count: 1
    confidence: 0.2
    value label: SH2 domain
  P527:
    value: Q24719835
    source count: 1
    confidence: 0.2
    value label: tyrosine-protein kinase, catalytic domain
  P637:
    value: NP_001036194
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001036212
    source count: 1
    confidence: 0.2
  P637:
    value: NP_005239
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006710515
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011539312
    source count: 1
    confidence: 0.2
  P680:
    value: Q14840131
    source count: 1
    confidence: 0.2
    value label: transferase activity
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding
  P680:
    value: Q14820641
    source count: 1
    confidence: 0.2
    value label: protein kinase activity
  P680:
    value: Q21097212
    source count: 2
    confidence: 0.4
    value label: immunoglobulin receptor binding
  P680:
    value: Q14863082
    source count: 1
    confidence: 0.2
    value label: kinase activity
  P681:
    value: Q79899
    source count: 1
    confidence: 0.2
    value label: cytoplasm

value: Q220599
source count: 3
confidence: 0.6
value label: cytosol

value: Q14353100
source count: 1
confidence: 0.2
value label: cell projection

value: Q14349455
source count: 1
confidence: 0.2
value label: membrane

value: Q14905148
source count: 1
confidence: 0.2
value label: extrinsic component of cytoplasmic side of plasma membrane

value: Q210861
source count: 1
confidence: 0.2
value label: cell differentiation

value: Q14913302
source count: 2
confidence: 0.4
value label: regulation of innate immune response

value: Q14863968
source count: 1
confidence: 0.2
value label: Fc-gamma receptor signaling pathway involved in phagocytosis

value: Q242736
source count: 1
confidence: 0.2
value label: phosphorylation

value: Q14863362
source count: 1
confidence: 0.2
value label: transmembrane receptor protein tyrosine kinase signaling pathway

value: Q17928333
source count: 1
confidence: 0.2
value label: FGR

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000363115
source count: 1
confidence: 0.2

value: ENSP00000363116
source count: 1
confidence: 0.2

value: ENSP00000363117
source count: 1
confidence: 0.2

value: ENSP00000382126
source count: 1
confidence: 0.2

value: ENSP00000407670
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: A quantitative protein interaction network for the ErbB receptors using protein microarrays
stated in qid: Q24293746
retrieved: 2019-04-08

source: The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
stated in qid: Q24292828
retrieved: 2019-04-08

source: Analysis of 5-lipoxygenase phosphorylation on molecular level by MALDI-MS
stated in qid: Q24298266
retrieved: 2019-04-08

source: Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
stated in qid: Q24294625
retrieved: 2019-04-08

source: Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
stated in qid: Q24297748
retrieved: 2019-04-08

source: Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils
stated in qid: Q24309479
retrieved: 2019-04-08

source: fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection
stated in qid: Q24294929
retrieved: 2018-01-01

source: GOA
stated in qid: Q28018111
retrieved: 2018-01-01

source: Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils
stated in qid: Q24305952
retrieved: 2018-01-01

source: Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis
stated in qid: Q28115092
retrieved: 2018-01-01

source: Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis
stated in qid: Q28115947
retrieved: 2018-01-01

source: Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils
stated in qid: Q24309479
retrieved: 2017-09-26

source: Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1
stated in qid: Q28902456
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection
stated in qid: Q24294929
retrieved: 2019-04-08

source: Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils
stated in qid: Q24305952
retrieved: 2019-04-08

source: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
stated in qid: Q24311780
retrieved: 2017-09-26

source: Activation of SRC family kinases in human neutrophils. Evidence that p58C-FGR and p53/56LYN redistributed to a Triton X-100-insoluble cytoskeletal fraction, also enriched in the caveolar protein caveolin, display an enhanced kinase activity
stated in qid: Q24323172
retrieved: 2019-04-08

source: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
stated in qid: Q24311780
retrieved: 2019-04-08

source: Clustering of beta(2)-integrins on human neutrophils activates dual signaling pathways to PtdIns 3-kinase
stated in qid: Q22253402
retrieved: 2019-04-08

source: Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family
stated in qid: Q24294855
retrieved: 2019-04-08

source: Clustering of beta(2)-integrins on human neutrophils activates dual signaling pathways to PtdIns 3-kinase
stated in qid: Q22253402
retrieved: 2017-09-26

source: Specific expression of human c-fgr in natural immunity effector cells
stated in qid: Q24318870
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21097222
domain: protein
level: standard
html url: https://4ort.xyz/entity/fgr-proto-oncogene-src-family-tyrosine-kinase-q21097222
markdown url: https://4ort.xyz/entity/fgr-proto-oncogene-src-family-tyrosine-kinase-q21097222.md
facts url summary: https://4ort.xyz/entity/fgr-proto-oncogene-src-family-tyrosine-kinase-q21097222/facts.json
facts url standard: https://4ort.xyz/entity/fgr-proto-oncogene-src-family-tyrosine-kinase-q21097222/facts.json
facts url full: https://4ort.xyz/entity/fgr-proto-oncogene-src-family-tyrosine-kinase-q21097222/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-06T03:43:39.676015Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:12:06.018882+00:00Z