# Fas (TNF receptor superfamily member 6)

> mammalian protein found in Mus musculus

**Wikidata**: [Q21494938](https://www.wikidata.org/wiki/Q21494938)  
**Source**: https://4ort.xyz/entity/fas-tnf-receptor-superfamily-member-6-


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P25446)
3. Q20641742
4. [Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
5. [FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
6. [A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
7. [A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
8. [TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
9. [Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
10. [Caveolin-1 mediates Fas–BID signaling in hyperoxia-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
11. [The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
12. [PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
13. [Palmitoylation is required for efficient Fas cell death signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
14. [TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25446&geneProductId=UniProtKB:P25446)
17. [A naturally occurring soluble isoform of murine Fas generated by alternative splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
18. [Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
19. [Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
20. [M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
21. [Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
22. [The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
23. [Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
24. [Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25446&geneProductId=UniProtKB:P25446)
25. [Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
26. [Age-dependent reduction of Bcl-2 expression in peripheral T cells of lpr and gld mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
27. [Fas is not essential for lamina propria T lymphocyte homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
28. [Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
29. [p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
30. [Down regulation of Bcl-2 is the first step on Fas-mediated apoptosis of male reproductive tract](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
31. [The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
32. [Several different cell surface molecules control negative selection of medullary thymocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
33. [Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
34. [Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
35. [Mice Defective in Two Apoptosis Pathways in the Myeloid Lineage Develop Acute Myeloblastic Leukemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
36. [NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
37. [tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
38. [MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
39. [Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
40. [The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
41. [Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
42. [Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
43. [Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
44. [YAP1 increases organ size and expands undifferentiated progenitor cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
45. [cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
46. [Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
47. [CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446)
48. ensembl Release 95