# Fas cell surface death receptor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q1649375](https://www.wikidata.org/wiki/Q1649375)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Fas_receptor)  
**Source**: https://4ort.xyz/entity/fas-cell-surface-death-receptor


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P25445)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
6. [Whole-exome-sequencing-based discovery of human FADD deficiency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
7. [A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
8. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
9. [Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
10. [A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
11. [Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
12. [Caveolin-1 mediates Fas–BID signaling in hyperoxia-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
13. [Apoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
14. [Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
15. [Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
16. [FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
17. [FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
18. [Modulation of the CD95-Induced Apoptosis: The Role of CD95 N-Glycosylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
19. [Inhibition of Daxx-mediated apoptosis by heat shock protein 27](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
20. [Negative regulation of Fas-mediated apoptosis by FAP-1 in human cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
21. [Yes and PI3K bind CD95 to signal invasion of glioblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
22. [PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
23. [The role of receptor internalization in CD95 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
24. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
25. [Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445)
26. [Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445)
27. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445)
28. [Structural insights into the mechanism of calmodulin binding to death receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
29. [Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
30. [Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
31. [The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445)
32. [Vesicles released by activated T cells induce both Fas-mediated RIP-dependent apoptotic and Fas-independent nonapoptotic cell deaths](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445)
33. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445)
34. [Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
35. [Vesicles released by activated T cells induce both Fas-mediated RIP-dependent apoptotic and Fas-independent nonapoptotic cell deaths](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
36. [The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
37. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
38. [Expression of the Bcl-2 protein BAD promotes prostate cancer growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
39. [p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-kappaB activity and Fas expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
40. [Effect of age and apoptosis on the mouse homologue of the huWRN gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
41. [Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445)
42. [Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25445&geneProductId=UniProtKB:P25445)
43. [Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
44. [Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
45. [Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
46. [Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
47. [Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25445)
48. Ensembl Release 99
49. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)