# Fas associated via death domain

> mammalian protein found in Homo sapiens

**Wikidata**: [Q994646](https://www.wikidata.org/wiki/Q994646)  
**Source**: https://4ort.xyz/entity/fas-associated-via-death-domain


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13158)
3. Q20641742
4. [A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
5. [Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
6. [A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
7. [Whole-exome-sequencing-based discovery of human FADD deficiency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
8. [Caspase-10 is an initiator caspase in death receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
9. [Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
10. [Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
11. [DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
12. [Ribosomal protein S3 interacts with TRADD to induce apoptosis through caspase dependent JNK activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
13. [PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
14. [Casper is a FADD- and caspase-related inducer of apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
15. [Caveolin-1 mediates Fas–BID signaling in hyperoxia-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
16. [PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
17. [Pick your poison: The Ripoptosome, a cell death platform regulating apoptosis and necroptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
18. [Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
19. [RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
20. [Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
21. [The apoptotic signaling pathway activated by Toll-like receptor-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
22. [Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
23. [A type III effector antagonizes death receptor signalling during bacterial gut infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
24. [The Fas-FADD death domain complex structure unravels signalling by receptor clustering](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
25. [Phosphorylation by polo-like kinase 1 induces the tumor-suppressing activity of FADD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
26. [Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
27. [ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
28. [Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
29. [An Evolution-Guided Analysis Reveals a Multi-Signaling Regulation of Fas by Tyrosine Phosphorylation and its Implication in Human Cancers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
30. [Yes and PI3K bind CD95 to signal invasion of glioblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
31. [Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
32. [Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
33. [Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
34. [The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
35. [The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
36. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
37. [The role of receptor internalization in CD95 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
38. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
39. [NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
40. [Modulation of the CD95-Induced Apoptosis: The Role of CD95 N-Glycosylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
41. [Defects in death-inducing signalling complex formation prevent JNK activation and Fas-mediated apoptosis in DU 145 prostate carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
42. [The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
43. [TWEAK Induces Apoptosis through a Death-signaling Complex Comprising Receptor-interacting Protein 1 (RIP1), Fas-associated Death Domain (FADD), and Caspase-8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
44. [The seventh zinc finger motif of A20 is required for the suppression of TNF‐α‐induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
45. [FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
46. [TNF-alpha induces two distinct caspase-8 activation pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
47. [Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
48. [Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
49. [IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)
50. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158)