# Farnesyltransferase, CAAX box, beta

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28556274](https://www.wikidata.org/wiki/Q28556274)  
**Source**: https://4ort.xyz/entity/farnesyltransferase-caax-box-beta


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q02293)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
5. [Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
6. [cDNA cloning and expression of the peptide-binding β subunit of rat p21rasfarnesyltransferase, the counterpart of yeast DPR1/RAM1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
8. [Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
9. [Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
10. [Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
11. [Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
12. [Biochemical and structural studies with prenyl diphosphate analogues provide insights into isoprenoid recognition by protein farnesyl transferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
13. [The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
14. [Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
15. [Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
16. [Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
17. [Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
18. [Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
19. [Role of the Carboxyterminal Residue in Peptide Binding to Protein Farnesyltransferase and Protein Geranylgeranyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
20. [Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
21. [TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
22. [Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein farnesylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)
23. [Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02293)