# Farnesyltransferase, CAAX box, beta

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21130772](https://www.wikidata.org/wiki/Q21130772)  
**Source**: https://4ort.xyz/entity/farnesyltransferase-caax-box-beta-q21130772


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P49356)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49356)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49356&geneProductId=UniProtKB:P49356)
6. [Conversion of Protein Farnesyltransferase to a Geranylgeranyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49356&geneProductId=UniProtKB:P49356)
7. [The Protein Farnesyltransferase Regulates HDAC6 Activity in a Microtubule-dependent Manner](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49356&geneProductId=UniProtKB:P49356)
8. [Crystallographic Analysis Reveals that Anticancer Clinical Candidate L-778,123 Inhibits Protein Farnesyltransferase and Geranylgeranyltransferase-I by Different Binding Modes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49356)
9. [The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49356)
10. [Dual Protein Farnesyltransferase−Geranylgeranyltransferase-I Inhibitors as Potential Cancer Chemotherapeutic Agents](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49356)
11. [3-Aminopyrrolidinone Farnesyltransferase Inhibitors: Design of Macrocyclic Compounds with Improved Pharmacokinetics and Excellent Cell Potency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49356)
12. [Crystallographic Analysis of CaaX Prenyltransferases Complexed with Substrates Defines Rules of Protein Substrate Selectivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49356)
13. [Crystal Structures of the Anticancer Clinical Candidates R115777 (Tipifarnib) and BMS-214662 Complexed with Protein Farnesyltransferase Suggest a Mechanism of FTI Selectivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49356)
14. [Conversion of Protein Farnesyltransferase to a Geranylgeranyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49356)
15. [The Protein Farnesyltransferase Regulates HDAC6 Activity in a Microtubule-dependent Manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49356)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49356)
17. Ensembl Release 99