# Farnesyltransferase, CAAX box, alpha

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28557364](https://www.wikidata.org/wiki/Q28557364)  
**Source**: https://4ort.xyz/entity/farnesyltransferase-caax-box-alpha-q28557364


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q04631)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
5. [Cloning and expression of a cDNA encoding the alpha subunit of rat p21ras protein farnesyltransferase.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
6. [Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
8. [TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
9. [Crystallographic Analysis Reveals that Anticancer Clinical Candidate L-778,123 Inhibits Protein Farnesyltransferase and Geranylgeranyltransferase-I by Different Binding Modes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
10. [Structure of mammalian protein geranylgeranyltransferase type‐I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
11. [Crystal Structure of Protein Farnesyltransferase at 2.25 Angstrom Resolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
12. [Crystallographic Analysis of CaaX Prenyltransferases Complexed with Substrates Defines Rules of Protein Substrate Selectivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
13. [Crystal Structures of the Anticancer Clinical Candidates R115777 (Tipifarnib) and BMS-214662 Complexed with Protein Farnesyltransferase Suggest a Mechanism of FTI Selectivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
14. [Biochemical and Structural Studies with Prenyl Diphosphate Analogues Provide Insights into Isoprenoid Recognition by Protein Farnesyl Transferase,](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
15. [The basis for K-Ras4B binding specificity to protein farnesyl-transferase revealed by 2 Å resolution ternary complex structures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
16. [Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
17. [Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
18. [Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
19. [Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure−Activity Relationships](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
20. [Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
21. [Role of the Carboxyterminal Residue in Peptide Binding to Protein Farnesyltransferase and Protein Geranylgeranyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
22. [Dominant-Negative α-Subunit of Farnesyl- and Geranyltransferase Inhibits Glucose-Stimulated, but Not KCl-Stimulated, Insulin Secretion in INS 832/13 Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
23. [Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase‐1 inhibitor GGTI‐298 disrupts MAP kinase activation and G1‐S transition in Ki‐Ras‐overexpressing transformed adrenocortical cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
24. [Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein farnesylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
25. [Inhibition of Protein Geranylgeranylation Causes a Superinduction of Nitric-oxide Synthase-2 by Interleukin-1β in Vascular Smooth Muscle Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
26. [Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: Cleavage of the common α subunit during apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631)
27. ensembl Release 106