# Farnesyltransferase, CAAX box, alpha

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21118153](https://www.wikidata.org/wiki/Q21118153)  
**Source**: https://4ort.xyz/entity/farnesyltransferase-caax-box-alpha-q21118153


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P49354)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354)
5. [cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354)
6. [Conversion of Protein Farnesyltransferase to a Geranylgeranyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354)
7. [The Protein Farnesyltransferase Regulates HDAC6 Activity in a Microtubule-dependent Manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354)
8. [cDNA Cloning of the Two Subunits of Human CAAX Farnesyltransferase and Chromosomal Mapping of FNTA and FNTB Loci and Related Sequences](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49354&geneProductId=UniProtKB:P49354)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49354&geneProductId=UniProtKB:P49354)
10. [Conversion of Protein Farnesyltransferase to a Geranylgeranyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49354&geneProductId=UniProtKB:P49354)
11. [The Protein Farnesyltransferase Regulates HDAC6 Activity in a Microtubule-dependent Manner](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49354&geneProductId=UniProtKB:P49354)
12. [Crystallographic Analysis Reveals that Anticancer Clinical Candidate L-778,123 Inhibits Protein Farnesyltransferase and Geranylgeranyltransferase-I by Different Binding Modes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354)
13. [The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354)
14. [Dual Protein Farnesyltransferase−Geranylgeranyltransferase-I Inhibitors as Potential Cancer Chemotherapeutic Agents](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354)
15. [3-Aminopyrrolidinone Farnesyltransferase Inhibitors: Design of Macrocyclic Compounds with Improved Pharmacokinetics and Excellent Cell Potency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354)
16. [Crystallographic Analysis of CaaX Prenyltransferases Complexed with Substrates Defines Rules of Protein Substrate Selectivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354)
17. [Crystal Structures of the Anticancer Clinical Candidates R115777 (Tipifarnib) and BMS-214662 Complexed with Protein Farnesyltransferase Suggest a Mechanism of FTI Selectivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354)
18. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354)
19. [cDNA Cloning of the Two Subunits of Human CAAX Farnesyltransferase and Chromosomal Mapping of FNTA and FNTB Loci and Related Sequences](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354)
20. [The p21 RAS Farnesyltransferase α Subunit in TGF-β and Activin Signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49354&geneProductId=UniProtKB:P49354)
21. [The p21 RAS Farnesyltransferase α Subunit in TGF-β and Activin Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354)
22. [cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49354&geneProductId=UniProtKB:P49354)
23. [Characterization of recombinant human farnesyl-protein transferase: Cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49354&geneProductId=UniProtKB:P49354)
24. [Characterization of recombinant human farnesyl-protein transferase: Cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49354)
25. Ensembl Release 99