# F2R like trypsin receptor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21115613](https://www.wikidata.org/wiki/Q21115613)  
**Source**: https://4ort.xyz/entity/f2r-like-trypsin-receptor-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P55085)
3. Q20641742
4. [Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085)
6. [Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085)
7. [Structural insight into allosteric modulation of protease-activated receptor 2.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
9. [Disulfide isomerization switches tissue factor from coagulation to cell signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
10. [Factor X/Xa Elicits Protective Signaling Responses in Endothelial Cells Directly via PAR-2 and Indirectly via Endothelial Protein C Receptor-dependent Recruitment of PAR-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
11. [Systematic protein-protein interaction mapping for clinically relevant human GPCRs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
12. [Proteinase‐activated receptors, nucleotide P2Y receptors, and μ‐opioid receptor‐1B are under the control of the type I transmembrane proteins p23 and p24A in post‐Golgi trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
13. [c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
14. [Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
15. [beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
16. [p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
17. [Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
18. [Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
19. [Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
20. [Structural insight into allosteric modulation of protease-activated receptor 2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
21. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
22. [ALIX binds a YPX3L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
23. [Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085)
24. [Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
25. [Factor X/Xa Elicits Protective Signaling Responses in Endothelial Cells Directly via PAR-2 and Indirectly via Endothelial Protein C Receptor-dependent Recruitment of PAR-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55085&geneProductId=UniProtKB:P55085)
26. [Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
27. [Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-γ on human neutrophils and monocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
28. [Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
29. [Trypsin Induces Activation and Inflammatory Mediator Release from Human Eosinophils Through Protease-Activated Receptor-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
30. [Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - A novel paradigm for G(q/11) linked GPCRs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
31. [Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
32. [TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different cell types: involvement of Src and PLC](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
33. [Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
34. [Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
35. [Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
36. [Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
37. [Neutrophil Proteinase 3 Acts on Protease-Activated Receptor-2 to Enhance Vascular Endothelial Cell Barrier Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55085)
38. Ensembl Release 99
39. Transporter Classification database