# F-box and WD repeat domain containing 7

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21113973](https://www.wikidata.org/wiki/Q21113973)  
**Source**: https://4ort.xyz/entity/f-box-and-wd-repeat-domain-containing-7-q21113973


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q969H0)
3. Q20641742
4. [Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
5. [Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
6. [Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
7. [Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
8. [Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
9. [UBE2QL1 is disrupted by a constitutional translocation associated with renal tumor predisposition and is a novel candidate renal tumor suppressor gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
10. [FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
11. [NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
12. [F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
13. [The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
14. [ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
15. [M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
16. [NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
17. [Cyclin C is a haploinsufficient tumour suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
18. [Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
19. [Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
20. [FBXW7‐mediated degradation of CCDC6 is impaired by ATM during DNA damage response in lung cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
21. [SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
22. [PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
23. [SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
24. [Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
25. [Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
26. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0)
27. [Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0)
28. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
29. [Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0)
30. [The ubiquitin-specific protease USP28 is required for MYC stability](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0)
31. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
32. [Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
33. [Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
34. [Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
35. [Fbw7 and Usp28 regulate myc protein stability in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0)
36. [Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
37. [Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0)
38. [Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0)
39. [Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
40. [Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0)
41. [SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
42. [NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0)
43. [An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0)
44. Ensembl Release 99
45. UMLS 2023