# Eukaryotic translation initiation factor 4E

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21172259](https://www.wikidata.org/wiki/Q21172259)  
**Source**: https://4ort.xyz/entity/eukaryotic-translation-initiation-factor-4e-q21172259


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P06730)
3. Q20641742
4. [Amino acid sequence of the mRNA cap-binding protein from human tissues](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06730&geneProductId=UniProtKB:P06730)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06730&geneProductId=UniProtKB:P06730)
6. [Translational homeostasis via the mRNA cap-binding protein, eIF4E](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06730&geneProductId=UniProtKB:P06730)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
8. [CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
9. [Tracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4E](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
10. [LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
11. [Rbm24, a target of p53, is necessary for proper expression of p53 and heart development.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
12. [The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
13. [Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
14. [The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
15. [Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
16. [Quantitative proteomics identifies Gemin5, a scaffolding protein involved in ribonucleoprotein assembly, as a novel partner for eukaryotic initiation factor 4E](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
17. [Regulation of protein synthesis by inducible wild-type p53 in human lung carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
18. [Local control of a disorder-order transition in 4E-BP1 underpins regulation of translation via eIF4E.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
19. [Sumoylation of eIF4E activates mRNA translation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
20. [Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
21. [eIF4G is required for the pioneer round of translation in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
22. [An empirical framework for binary interactome mapping](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
23. [Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
24. [Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
25. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
26. [eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
27. [Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
28. [Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
29. [BTG4 is a meiotic cell cycle–coupled maternal-zygotic-transition licensing factor in oocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
30. [Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
31. [Characterization of mammalian eIF4E-family members](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
32. [Eukaryotic translation initiation is controlled by cooperativity effects within ternary complexes of 4E‐BP1, eIF4E, and the mRNA 5′ cap](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
33. [Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
34. [An oxygen-regulated switch in the protein synthesis machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
35. [4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
36. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
37. [The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
38. [Regulation of human eIF4E by 4E-BP1: binding analysis using surface plasmon resonance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
39. [A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
40. [Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
41. [Amino acid sequence of the mRNA cap-binding protein from human tissues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
42. [Identification of gemin5 as a novel 7-methylguanosine cap-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06730&geneProductId=UniProtKB:P06730)
43. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06730&geneProductId=UniProtKB:P06730)
44. [Identification of gemin5 as a novel 7-methylguanosine cap-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
45. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
46. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
47. [Translational homeostasis via the mRNA cap-binding protein, eIF4E](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
48. [Knockdown of human COX17 affects assembly and supramolecular organization of cytochrome c oxidase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
49. [Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730)
50. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P06730&geneProductId=UniProtKB:P06730)